Implications of Cellular Aging in Cardiac Reprogramming

Frontiers in Cardiovascular Medicine
Fabiana Passaro, Gianluca Testa

Abstract

Aging is characterized by a chronic functional decline of organ systems which leads to tissue dysfunction over time, representing a risk factor for diseases development, including cardiovascular. The aging process occurring in the cardiovascular system involves heart and vessels at molecular and cellular level, with subsequent structural modifications and functional impairment. Several modifications involved in the aging process can be ascribed to cellular senescence, a biological response that limits the proliferation of damaged cells. In physiological conditions, the mechanism of cellular senescence is involved in regulation of tissue homeostasis, remodeling, and repair. However, in some conditions senescence-driven tissue repair may fail, leading to the tissue accumulation of senescent cells which in turn may contribute to tumor promotion, aging, and age-related diseases. Cellular reprogramming processes can reverse several age-associated cell features, such as telomere length, DNA methylation, histone modifications and cell-cycle arrest. As such, induced Pluripotent Stem Cells (iPSCs) can provide models of progeroid and physiologically aged cells to gain insight into the pathogenesis of such conditions, to drive the develop...Continue Reading

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Citations

Oct 16, 2020·Clinical Oral Investigations·Jade Ormondes de FariasTaia Maria Berto Rezende
Apr 4, 2021·Metabolites·Giorgia Di BenedettoFabiana Passaro
May 14, 2021·Advanced Drug Delivery Reviews·Fabiana PassaroGianluca Testa
Aug 11, 2021·International Journal of Cardiology·Arturo GiordanoCorrado Tamburino
Oct 1, 2021·Frontiers in Cell and Developmental Biology·Martina TufanoMaria Fiammetta Romano

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Methods Mentioned

BETA
transgenic

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