Implications of COPD in patients admitted to the intensive care unit by community-acquired pneumonia

The European Respiratory Journal
Jordi RelloM Bodi

Abstract

The mortality rate of chronic obstructive pulmonary disease (COPD) patients with community-acquired pneumonia (CAP) is reported to be low. However, studies carried out to date have included <20% of critically ill patients. The current authors performed a secondary analysis of a prospective study evaluating 428 immunocompetent patients admitted to the intensive care unit (ICU) for severe CAP. In total, 176 COPD patients were compared with 252 non-COPD patients. In COPD patients, ICU mortality (odds ratio (OR) 1.58; 95% confidence interval (CI) 1.01-1.43) and mechanical ventilation (OR 2.78; 95% CI 1.63-4.74) rates were higher than in non-COPD patients. The ICU mortality was 39% for COPD patients initially intubated and 50% for those who failed noninvasive ventilation. The proportion of patients who were males, aged >/=70 yrs, smokers and who had chronic heart disease or Pseudomonas aeruginosa were higher in COPD patients. Inappropriate empirical antibiotic therapy was associated with higher mortality (OR 3.8; 95% CI 1.19-12.6). ICU mortality in COPD patients with adequate therapy was associated with bilateral pneumonia (OR 2.32; 95% CI 1.18-4.53) and shock (OR 3.53; 95% CI 1.31-9.71). In conclusion, chronic obstructive pulmonary...Continue Reading

Citations

Apr 11, 2009·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·E CalboJ Garau
May 3, 2011·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·T Welte
May 31, 2008·Current Infectious Disease Reports·Pierre Ernst, Samy Suissa
Nov 11, 2011·QJM : Monthly Journal of the Association of Physicians·B MesserS V Baudouin
Apr 25, 2007·Critical Care Medicine·Alejandro RodríguezUNKNOWN CAPUCI Study Group
May 25, 2007·Critical Care Medicine·Stijn Blot, Pieter Depuydt
Sep 29, 2007·Critical Care Medicine·Stijn I BlotUNKNOWN Community-Acquired Pneumonia Intensive Care Units (CAPUCI) Study Investigators
Dec 14, 2007·Critical Care Medicine·Alejandro Rodríguez, Jordi Rello
Mar 6, 2012·Current Opinion in Pulmonary Medicine·Gennaro De PascaleMassimo Antonelli
Apr 23, 2011·American Journal of Respiratory and Critical Care Medicine·Dennis ChenEric M Mortensen
Jan 6, 2009·Critical Care : the Official Journal of the Critical Care Forum·Jordi Rello
Jun 11, 2010·Critical Care : the Official Journal of the Critical Care Forum·Isaline CoquetElie Azoulay
Jul 25, 2013·International Journal of Chronic Obstructive Pulmonary Disease·Antonio M Esquinas RodriguezNicolino Ambrosino
Mar 19, 2014·Journal of Critical Care·Aykut CilliHakan Erdem
Jun 12, 2013·European Journal of Internal Medicine·Gurdeep Singh MannuPhyo Kyaw Myint
Dec 11, 2008·Intensive Care Medicine·Alejandro RodriguezUNKNOWN Community-Acquired Pneumonia Intensive Care Units (CAPUCI) Study Investigators
Jul 31, 2012·The British Journal of Radiology·F OkadaH Mori
Mar 17, 2010·QJM : Monthly Journal of the Association of Physicians·A SinganayagamA T Hill
Sep 5, 2012·Expert Review of Clinical Pharmacology·Juan F FernandezMarcos I Restrepo
Oct 11, 2008·Expert Review of Vaccines·Ulrich Baumann
Feb 11, 2014·Clinics in Chest Medicine·Kamen Rangelov, Sanjay Sethi
Oct 8, 2013·Critical Care Clinics·Hasan M Al-DorziYaseen M Arabi
Mar 12, 2011·Chest·Alejandro RodríguezJordi Rello
Jan 2, 2013·Medicina clínica·Antoni TorresUNKNOWN Grupo de la Guía Multidisciplinar para el Manejo de la Neumonía Adquirida en la Comunidad
Mar 27, 2012·Médecine et maladies infectieuses·J Obert, P-R Burgel
Mar 16, 2011·Revue des maladies respiratoires·H N BuiG Hilbert
Aug 12, 2009·Infectious Disease Clinics of North America·Marcos I Restrepo, Antonio Anzueto
Apr 15, 2008·Emergency Medicine Clinics of North America·Joseph F Plouffe, Daniel R Martin
Apr 12, 2013·International Journal of Clinical Practice·Y K LokeP K Myint

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