Implications of excess weight on kidney donation: Long-term consequences of donor nephrectomy in obese donors

Surgery
Oscar Kenneth SerranoRaja Kandaswamy

Abstract

An elevated body mass index (>30 kg/m2) has been a relative contraindication for living kidney donation; however, such donors have become more common. Given the association between obesity and development of diabetes, hypertension, and end-stage renal disease, there is concern about the long-term health of obese donors. Donor and recipient demographics, intraoperative parameters, complications, and short- and long-term outcomes were compared between contemporaneous donors-obese donors (body mass index ≥30 kg/m2) versus nonobese donors (body mass index <30 kg/m2). Between the years 1975 and 2014, we performed 3,752 donor nephrectomies; 656 (17.5%) were obese donors. On univariate analysis, obese donors were more likely to be older (P < .01) and African American (P < .01) and were less likely to be a smoker at the time of donation (P = .01). Estimated glomerular filtration rate at donation was higher in obese donors (115 ± 36 mL/min/1.73m2) versus nonobese donors (97 ± 22 mL/min/1.73m2; P < .001). There was no difference between groups in intraoperative and postoperative complications; but intraoperative time was longer for obese donors (adjusted P < .001). Adjusted postoperative length of stay (LOS) was longer (adjusted P = .01)...Continue Reading

Citations

Mar 13, 2019·Clinical Journal of the American Society of Nephrology : CJASN·Krista L LentineDorry L Segev
Oct 23, 2019·Surgical Endoscopy·Lilli SchusslerEdward H Chin
Dec 14, 2019·Current Opinion in Organ Transplantation·Luuk B Hilbrands
Jan 4, 2020·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Elham Asgari, Rachel M Hilton
Jun 4, 2020·Current Opinion in Organ Transplantation·Jim KimThin Thin Maw
Jul 9, 2020·Experimental and Clinical Transplantation : Official Journal of the Middle East Society for Organ Transplantation·Yassamine Bentata
Sep 26, 2019·Transplant International : Official Journal of the European Society for Organ Transplantation·Adnan Sharif
Nov 30, 2019·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·François GaillardChristophe Legendre
Feb 26, 2020·Obesity Surgery·Alexander M FagensonMichael A Edwards
Jun 25, 2021·World Journal of Transplantation·Mahmoud M MohamedKarim M Soliman
Jul 12, 2021·Transplantation Proceedings·Bekir TanrioverDavid J Cohen

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