Implications of functional anatomy on information processing in the deep cerebellar nuclei.

Frontiers in Cellular Neuroscience
Yuval BaumelDana Cohen

Abstract

The cerebellum has been implicated as a major player in producing temporal acuity. Theories of cerebellar timing typically emphasize the role of the cerebellar cortex while overlooking the role of the deep cerebellar nuclei (DCN) that provide the sole output of the cerebellum. Here we review anatomical and electrophysiological studies to shed light on the DCN's ability to support temporal pattern generation in the cerebellum. Specifically, we examine data on the structure of the DCN, the biophysical properties of DCN neurons and properties of the afferent systems to evaluate their contribution to DCN firing patterns. In addition, we manipulate one of the afferent structures, the inferior olive (IO), using systemic harmaline injection to test for a network effect on activity of single DCN neurons in freely moving animals. Harmaline induces a rhythmic firing pattern of short bursts on a quiescent background at about 8 Hz. Other neurons become quiescent for long periods (seconds to minutes). The observed patterns indicate that the major effect harmaline exerts on the DCN is carried indirectly by the inhibitory Purkinje cells (PCs) activated by the IO, rather than by direct olivary excitation. Moreover, we suggest that the DCN resp...Continue Reading

Citations

Jul 27, 2011·Biological cybernetics·Rodrigo Alvarez-Icaza, Kwabena Boahen
Jul 24, 2010·The Cerebellum·Maureen DennisJack M Fletcher
Sep 4, 2015·Cerebellum & Ataxias·Maryam Rahimi-BalaeiHassan Marzban
Jul 28, 2016·Frontiers in Cellular Neuroscience·Egidio D'AngeloEduardo Ros
Jul 2, 2021·Frontiers in Neural Circuits·Moritoshi HironoYuchio Yanagawa
Nov 11, 2021·The Cerebellum·Mike Gilbert

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