Implications of glial nitric oxide in neurodegenerative diseases

Frontiers in Cellular Neuroscience
Jose Enrique YusteFrancisco Ros-Bernal

Abstract

Nitric oxide (NO) is a pleiotropic janus-faced molecule synthesized by nitric oxide synthases (NOS) which plays a critical role in a number of physiological and pathological processes in humans. The physiological roles of NO depend on its local concentrations, as well as its availability and the nature of downstream target molecules. Its double-edged sword action has been linked to neurodegenerative disorders. Excessive NO production, as the evoked by inflammatory signals, has been identified as one of the major causative reasons for the pathogenesis of several neurodegenerative diseases. Moreover, excessive NO synthesis under neuroinflammation leads to the formation of reactive nitrogen species and neuronal cell death. There is an intimate relation between microglial activation, NO and neuroinflammation in the human brain. The role of NO in neuroinflammation has been defined in animal models where this neurotransmitter can modulate the inflammatory process acting on key regulatory pathways, such as those associated with excitotoxicity processes induced by glutamate accumulation and microglial activation. Activated glia express inducible NOS and produce NO that triggers calcium mobilization from the endoplasmic reticulum, activ...Continue Reading

References

Oct 1, 1988·Annals of Neurology·P L McGeerE G McGeer
Jan 1, 1967·Biochimica Et Biophysica Acta·K F Tipton
Oct 1, 1983·Mechanisms of Ageing and Development·D Bhaskaran, E Radha
Mar 1, 1994·The Biochemical Journal·R G Knowles, S Moncada
Dec 8, 1994·Nature·L KobzikJ S Stamler
Jan 1, 1994·Developmental Neuroscience·C F BrosnanS C Lee
Jan 1, 1993·Proceedings of the National Academy of Sciences of the United States of America·J L BalligandT Michel
Sep 1, 1994·Circulation Research·D JanigroH R Winn
May 1, 1993·Biochemical Society Transactions·J S Beckman, J P Crow
Dec 19, 1995·Proceedings of the National Academy of Sciences of the United States of America·O BagasraH Koprowski
Mar 15, 1996·Circulation·P MohanS U Sys
May 1, 1997·Neuron·J S StamlerN J Sucher
May 26, 1998·Journal of Neuropathology and Experimental Neurology·P F GoodC W Olanow
Feb 5, 1999·Progress in Brain Research·A K Loihl, S Murphy
Feb 16, 1999·Brain Pathology·M R Cookson, P J Shaw
Aug 12, 1999·Cellular and Molecular Life Sciences : CMLS·P E ChabrierM Auguet
Oct 6, 2000·Nitric Oxide : Biology and Chemistry·E M GattoJ J Poderoso
Nov 14, 2000·The American Journal of Pathology·J E DudaJ Q Trojanowski
Dec 23, 2000·Molecular and Cellular Neurosciences·C KnottG P Wilkin
Jun 8, 2001·The American Journal of Pathology·J S LiuS C Lee
Jul 21, 2001·The Biochemical Journal·W K AldertonR G Knowles
Aug 7, 2001·Journal of Neuropathology and Experimental Neurology·A NunomuraM A Smith
Dec 26, 2001·Journal of Neuroscience Research·Patricia CassinaLuis Barbeito

❮ Previous
Next ❯

Citations

Feb 6, 2016·International Journal of Molecular Sciences·Gabor G Kovacs
Apr 26, 2016·Oxidative Medicine and Cellular Longevity·Dolores Limongi, Sara Baldelli
Jun 18, 2016·Frontiers in Neuroscience·Adriana Ximenes-da-Silva
Jun 9, 2016·Journal of Biochemical and Molecular Toxicology·Amina Ladjel-MendilFatima Laraba-Djebari
Jul 5, 2016·Biochimica Et Biophysica Acta·Bruna BellaverAndré Quincozes-Santos
Oct 25, 2016·Neurologia i neurochirurgia polska·Łukasz Smoliński, Anna Członkowska
Oct 21, 2016·Redox Biology·Calina BetlazarGuo-Jun Liu
Aug 17, 2016·International Journal of Molecular Sciences·Silvia GrottelliIlaria Bellezza
Aug 23, 2016·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Yu Jin KimSoo-Jin Jeong
Sep 24, 2016·Biochemical and Biophysical Research Communications·Clark A BriggsGrace E Stutzmann
Jan 4, 2017·Magnetic Resonance in Chemistry : MRC·Hyeji ShinKi Yong Lee
Feb 7, 2017·Nutritional Neuroscience·Larissa Daniele BoberminAndré Quincozes-Santos
Jan 27, 2017·Neural Regeneration Research·Cristina Maccallini, Rosa Amoroso
Jan 5, 2019·Chemical & Pharmaceutical Bulletin·Kyeong Wan WooKang Ro Lee
Jan 27, 2018·Cell Death & Disease·Christina Ising, Michael T Heneka
Feb 20, 2018·Translational Neurodegeneration·Sandesh PanthiKripa Gautam
Apr 8, 2016·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·Nesrine SifiFatima Laraba-Djebari
Sep 18, 2018·Current Neuropharmacology·Hiroshi MitomaChristiane S Hampe
Oct 30, 2016·Experimental Neurobiology·Gyun Jee SongKyoungho Suk
Oct 24, 2015·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Elvira ValeraEliezer Masliah
Jul 25, 2019·Current Pharmaceutical Design·Ligia J DominguezMiguel Angel Martinez-Gonzalez
Sep 11, 2020·Analytical Methods : Advancing Methods and Applications·Jay Sibbitts, Christopher T Culbertson
Sep 15, 2020·Journal of Alzheimer's Disease : JAD·Jade de OliveiraAndreza F de Bem
Jan 11, 2017·Molecular and Cellular Biochemistry·Bernardo Assein ArúsLarissa Daniele Bobermin
May 23, 2018·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Tian WangBing Han
Jun 2, 2016·Journal of Neuroinflammation·David B KurlandJ Marc Simard

❮ Previous
Next ❯

Related Concepts

Related Feeds

Astrocytes

Astrocytes are glial cells that support the blood-brain barrier, facilitate neurotransmission, provide nutrients to neurons, and help repair damaged nervous tissues. Here is the latest research.

Brain Aging

Here is the latest research on intrinsic and extrinsic factors, as well as pathways and mechanisms that underlie aging in the central nervous system.

Astrocytes & Neurodegeneration

Astrocytes are important for the health and function of the central nervous system. When these cells stop functioning properly, either through gain of function or loss of homeostatic controls, neurodegenerative diseases can occur. Here is the latest research on astrocytes and neurodegeneration.