Implications of Inflammasomes in Human Diseases: NLRP3 Inflammasome and Animal Models

Cornea
Tohru Sakimoto

Abstract

Danger-associated molecular patterns, such as nuclear or cytosolic proteins released outside the cell or exposed on the cell surface after tissue injury, and pathogen-associated molecular patterns, such as lipopolysaccharide, peptidoglycan, and nucleic acid, stimulate the formation of a large protein complex called the inflammasome. The inflammasome is a cytosolic complex of 3 proteins that cleaves and releases interleukin-1β. Recent studies have characterized a multitude of inflammasome ligands of both endogenous and exogenous origins. Moreover, using various animal models, the implications of inflammasomes in human diseases have been elucidated for multifaceted diseases such as metabolic syndrome, inflammatory bowel disease, Alzheimer disease, and certain inflammatory skin diseases. This article reviews several of these conditions and discusses the different models proposed for inflammasome involvement, including animal models of the cornea.

References

Apr 29, 1998·Dermatology : International Journal for Clinical and Investigative Dermatology·C C ZouboulisC E Orfanos
Jul 23, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Jenny KimRobert L Modlin
Jan 13, 2006·Nature·Fabio MartinonJürg Tschopp
Jan 13, 2006·Nature·Sanjeev MariathasanVishva M Dixit
Apr 13, 2007·The New England Journal of Medicine·Claus M LarsenMarc Y Donath
Jul 8, 2008·Nature Immunology·Annett HalleDouglas T Golenbock
Sep 1, 2009·The Journal of Immunology : Official Journal of the American Association of Immunologists·Raúl Muñoz-PlanilloGabriel Núñez
Dec 17, 2009·The Journal of Immunology : Official Journal of the American Association of Immunologists·Karolin MeixenbergerBastian Opitz
Apr 14, 2010·The Journal of Experimental Medicine·Irving C AllenJenny P-Y Ting
Aug 20, 2010·Lancet·Christopher M Burns, Robert L Wortmann
Sep 28, 2010·Inflammatory Bowel Diseases·Simon A HirotaPaul L Beck
Dec 3, 2010·Nature·Rongbin ZhouJürg Tschopp
Mar 12, 2011·Cellular Microbiology·Navkiran GillB Brett Finlay
Sep 2, 2011·Lancet·Hywel C WilliamsSarah Garner
Jan 20, 2012·Nature·Till StrowigRichard Flavell
Jun 27, 2012·Proceedings of the National Academy of Sciences of the United States of America·Tomohiko MurakamiTiffany Horng
Jul 26, 2013·The Journal of Investigative Dermatology·Min QinJenny Kim
Oct 26, 2013·The Journal of Investigative Dermatology·Magdalena KistowskaLars E French
May 14, 2014·The Journal of Investigative Dermatology·Zheng Jun LiMyung Im
May 16, 2014·Proceedings of the National Academy of Sciences of the United States of America·Sivapriya Kailasan VanajaJohn M Leong
May 20, 2014·Experimental Eye Research·Qinxiang ZhengWei Chen
Oct 8, 2014·The Journal of Biological Chemistry·Masahiro OkadaHidenori Ichijo
Jan 23, 2015·The Journal of Immunology : Official Journal of the American Association of Immunologists·Mausita KarmakarEric Pearlman
Sep 19, 2015·Nature Immunology·Shusaku T ShibutaniTamotsu Yoshimori
Oct 31, 2015·Journal of Leukocyte Biology·Fernanda GimenezBarry T Rouse
Dec 8, 2015·Cell·Roni NowarskiRichard A Flavell
Feb 16, 2016·Nature Communications·Mausita KarmakarEric Pearlman

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Citations

Oct 9, 2019·Cells·Chun Wang, Gabriel Mbalaviele
Jul 12, 2020·Diabetes/metabolism Research and Reviews·Roma PahwaIshwarlal Jialal
Jul 23, 2021·Toxicology in Vitro : an International Journal Published in Association with BIBRA·Tao LiuChunwei Lan

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