Implications of KRAS mutations in acquired resistance to treatment in NSCLC

Oncotarget
Marzia Del ReRomano Danesi

Abstract

KRAS is the most common and, simultaneously, the most ambiguous oncogene implicated in human cancer. Despite KRAS mutations were identified in Non Small Cell Lung Cancers (NSCLCs) more than 20 years ago, selective and specific inhibitors aimed at directly abrogating KRAS activity are not yet available. Nevertheless, many therapeutic approaches have been developed potentially useful to treat NSCLC patients mutated for KRAS and refractory to both standard chemotherapy and targeted therapies.The focus of this review will be to provide an overview of the network related to the intricate molecular KRAS pathways, stressing on preclinical and clinical studies that investigate the predictive value of KRAS mutations in NSCLC patients. A bibliographic search of the Medline database was conducted for articles published in English, with the keywords KRAS, KRAS mutations in non-small cell lung cancer, KRAS and tumorigenesis, KRAS and TKIs, KRAS and chemotherapy, KRAS and monoclonal antibody, KRAS and immunotherapy, KRAS and drugs, KRAS and drug resistance.

References

Oct 3, 2002·Nature Medicine·Mirella LazarovPaul A Khavari
May 2, 2003·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Alex A AdjeiEverett E Vokes
May 8, 2004·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Fadlo R KhuriWaun Ki Hong
Sep 6, 2005·Biochimica Et Biophysica Acta·Bret B Friday, Alex A Adjei
May 30, 2006·Advances in Immunology·Charles G DrakeDrew M Pardoll
Apr 13, 2007·Biochimica Et Biophysica Acta·Krishnaraj RajalingamStefan Albert
May 17, 2007·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Erminia MassarelliIgnacio I Wistuba
Jun 2, 2007·Cell·Johannes L BosAlfred Wittinghofer
Apr 8, 2009·Proceedings of the American Thoracic Society·Gregory J RielyWilliam Pao
May 20, 2009·The Journal of Clinical Investigation·Martin L SosRoman K Thomas
Oct 15, 2009·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Andrew A Lane, Bruce A Chabner
Dec 22, 2009·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Chen MaoQing Chen
Apr 10, 2010·Nature Reviews. Molecular Cell Biology·Bart VanhaesebroeckBenoit Bilanges
Apr 17, 2010·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Joline S W LindEgbert F Smit
Apr 28, 2010·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Egbert F SmitPieter E Postmus
Dec 21, 2010·Annals of Oncology : Official Journal of the European Society for Medical Oncology·M C GarassinoM Broggini
Jan 13, 2011·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Ronan J KellyGiuseppe Giaccone
Jan 20, 2011·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Aidan G GilmartinSylvie G Laquerre
May 18, 2011·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·David R SpigelJohn D Hainsworth
Jul 23, 2011·Genes & Cancer·Esther Castellano, Julian Downward
Aug 19, 2011·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Gregory J RielyMichelle S Ginsberg
Jan 17, 2012·Journal of the National Cancer Institute·Nathan T IhleGarth Powis
Jan 20, 2012·Nature·Mel Greaves, Carlo C Maley
Mar 23, 2012·Nature Reviews. Cancer·Drew M Pardoll
May 16, 2012·Cancer Discovery·Edward S KimWaun K Hong
Jun 5, 2012·The New England Journal of Medicine·Suzanne L TopalianMario Sznol
Jul 11, 2012·Chinese Journal of Cancer·Peter M K Westcott, Minh D To
Sep 27, 2012·Molecular Cancer Therapeutics·Jaime AcquavivaDavid A Proia
Nov 28, 2012·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Jonathan W Goldman, Edward B Garon
Mar 26, 2013·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Petra MartinFrances A Shepherd
Apr 5, 2013·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Mark A SocinskiGeoffrey I Shapiro
Jun 1, 2013·Annals of Oncology : Official Journal of the European Society for Medical Oncology·S DeardenD Blowers
Jun 5, 2013·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Justin F GainorAlice T Shaw

❮ Previous
Next ❯

Citations

Aug 14, 2019·Pathology Oncology Research : POR·Hussein NassereddineAurélie Cazes
Sep 22, 2020·The New England Journal of Medicine·David S HongBob T Li
Dec 5, 2019·Therapeutic Advances in Medical Oncology·Marika CinauseroAndrea Ardizzoni
Oct 30, 2020·International Journal of Molecular Sciences·Polina V ShnaiderVictoria O Shender
Mar 6, 2021·European Journal of Medicinal Chemistry·Sitanshu S SinghSeetharama Jois
Feb 10, 2021·The Journal of Clinical Investigation·Niels HeemskerkMarjolein van Egmond
Apr 4, 2021·Cancers·Lisa Maria MustachioJason Roszik
Aug 22, 2021·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Colin R LindsayJulien Mazières
Aug 31, 2021·The Journal of Biological Chemistry·Ali E YesilkanalMarsha Rich Rosner

❮ Previous
Next ❯

Methods Mentioned

BETA
GTPase
nucleotide exchange
xenograft

Software Mentioned

CUSTOM
JUNIPER

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Proceedings of the American Thoracic Society
Gregory J RielyWilliam Pao
Vojnosanitetski pregled. Military-medical and pharmaceutical review
Gordana CvetkovićVukojica Karlicić
Lung Cancer : Journal of the International Association for the Study of Lung Cancer
Aristea KalikakiAlexandra Voutsina
Zhonghua yi xue yi chuan xue za zhi = Zhonghua yixue yichuanxue zazhi = Chinese journal of medical genetics
Feng LiuXiao-hua Hu
© 2022 Meta ULC. All rights reserved