PMID: 591984Dec 1, 1977

Implications of longitudinal muscle fibre splitting in neurogenic and myopathic disorders

Journal of Neurology, Neurosurgery, and Psychiatry
M Swash, M S Schwartz

Abstract

Histological and electromyographic studies indicate that longitudinal muscle fibre splitting is a common finding in neuromuscular disorders. Separated fragments derived by splitting may undergo degeneration or enlarge to become separate, innervated fibres, thus leading to an increased number of fibres within motor units. Splitting may, therefore, lead to the formation of clusters of fibres of uniform histochemical type, but of variable diameter and length, both in neurogenic and in myopathic disorders. Fibre splitting is thus a factor leading to functional compensation in these disorders.

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Citations

Mar 1, 1992·Muscle & Nerve·T H GootzenD F Stegeman
Jan 1, 1986·Virchows Archiv. A, Pathological Anatomy and Histopathology·L M Tang, M Swash
Apr 21, 2006·Histochemistry and Cell Biology·Anders ErikssonLars-Eric Thornell
Jun 1, 1979·Journal of the Neurological Sciences·F BeersiekM Swash
Jul 1, 1982·Journal of the Neurological Sciences·L C LimosY Kuroiwa
Feb 1, 1985·Journal of the Neurological Sciences·M SadehL Z Stern
Sep 9, 1999·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Zoia C Lateva, Kevin C McGill
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May 24, 2014·Skeletal Muscle·Christophe Pichavant, Grace K Pavlath
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Related Concepts

Nerve Impulses
Biopsy
Charcot-Marie-Tooth Disease, Type Ia (Disorder)
Surface Electromyography
Hypertrophy
Muscle
Muscular Dystrophy
Myositis, Proliferative
Necrosis
Foley-Denny-Brown Syndrome

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