Implications of perioperative allogeneic red blood cell transfusion on the immune-inflammatory response.

Hematology, Transfusion and Cell Therapy
José Eduardo Aguilar-NascimentoJosé O Bordin

Abstract

The allogeneic transfusion-related immunomodulation (TRIM) may be responsible for an increase in survival of renal transplants but in contrast it could increase the rate of bacterial infections or the recurrence rate of tumors post-operatively. This review focuses in the implications of perioperative allogeneic transfusions on the immune-inflammatory response of surgical transfused patients. ABTs modify immune functions in recipients including decrease of the number of lymphocytes; decrease the CD4 cells; decrease the CD4/CD8 T-cell ratio; decrease NK cells; and decrease the lymphocyte response to mitogens. TRIM effects may be mediated by allogeneic white cells present in blood products; soluble peptides present in transfused plasma; and/or biologic mediators released into the supernatant of blood units. A recent systematic review and meta-analysis including 36 clinical observational studies (n=174,036) concluded that perioperative ABTs not only decreased overall survival and reduced colorectal cancer-specific survival. Furthermore ABTs increased the rate of infectious, cardiac, pulmonary and anastomotic complications in colorectal cancer patients undergoing surgery. It has been demonstrated by laboratory tests that TRIM is ass...Continue Reading

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Citations

Nov 3, 2020·BioMed Research International·Raphael Iglesias de Oliveira VidalJoaquim Ribeiro Filho
Jul 16, 2021·Transplantation Direct·Caterina Giovanna ValentiniLuciana Teofili

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