Implications of polycystic ovary syndrome on oocyte development

Seminars in Reproductive Medicine
Daniel A Dumesic, David H Abbott

Abstract

Human follicle development requires the recruitment of primordial follicles into a cohort of growing follicles from which one follicle is selected to ovulate a mature oocyte. During this developmental process, complex endocrine and intraovarian paracrine signals create a changing intrafollicular hormonal milieu. With this microenvironment, appropriate cumulus cell-oocyte signaling governs oocyte developmental competence, defined as the ability of the oocyte to complete meiosis and undergo fertilization, embryogenesis, and term development. Many of these mechanisms are perturbed in polycystic ovary syndrome (PCOS), a heterogeneous syndrome characterized by ovarian hyperandrogenism, hyperinsulinemia from insulin resistance, and reduced fecundity. In addition to these endocrinopathies, PCOS also is characterized by paracrine dysregulation of follicle development by intraovarian proteins of the transforming growth factor-beta family. Consequently, PCOS patients undergoing ovarian stimulation for in vitro fertilization are at increased risks of impaired oocyte developmental competence, implantation failure, and pregnancy loss. Recent data demonstrate links between endocrine/paracrine factors and oocyte gene expression in PCOS and su...Continue Reading

References

Jul 1, 1983·Journal of Steroid Biochemistry·J C Osborn, R M Moor
Nov 1, 1993·The Journal of Clinical Endocrinology and Metabolism·C Y Andersen
Apr 1, 1995·The Journal of Clinical Endocrinology and Metabolism·J Tesarik, C Mendoza
Apr 1, 1994·Molecular and Cellular Endocrinology·S G HillierC D Smyth
Mar 1, 1994·Molecular Reproduction and Development·R J AsseyB Purwantara
Oct 15, 1993·Biochemical and Biophysical Research Communications·M SadatsukiY Taketani
Oct 1, 1996·The Journal of Clinical Endocrinology and Metabolism·S K AgarwalD A Magoffin
Jan 1, 1997·Critical Reviews in Eukaryotic Gene Expression·B Stebbins-Boaz, J D Richter
Apr 1, 1996·Molecular Reproduction and Development·T FairM Boland
May 1, 1997·Journal of Assisted Reproduction and Genetics·F CanoA Pellicer
Mar 24, 1998·Molecular Human Reproduction·A J JakimiukD A Magoffin
Jun 24, 1998·The Journal of Clinical Investigation·K A VendolaC A Bondy
Jul 14, 1998·The Journal of Clinical Endocrinology and Metabolism·S J WeilC A Bondy
Sep 19, 1998·Human Reproduction Update·R M MoorJ Fulka
Jun 3, 1999·Endocrinology and Metabolism Clinics of North America·S FranksD Willis
Jul 15, 1999·The Journal of Clinical Endocrinology and Metabolism·A J JakimiukD A Magoffin
Aug 12, 1999·The Journal of Clinical Endocrinology and Metabolism·J AaltonenO Ritvos
Aug 12, 1999·The Journal of Clinical Endocrinology and Metabolism·S WeilC A Bondy
Feb 25, 2000·Molecular and Cellular Endocrinology·J A ElvinM M Matzuk
Aug 30, 2000·Molecular and Cellular Endocrinology·S FranksD Willis
Mar 30, 2001·Reproduction : the Official Journal of the Society for the Study of Fertility·P G Knight, C Glister
Jun 9, 2001·The Journal of Clinical Endocrinology and Metabolism·D A DumesicA S McNeilly

❮ Previous
Next ❯

Citations

Sep 22, 2009·BMC Genomics·Md Munir HossainDawit Tesfaye
May 15, 2010·Reproductive Biology and Endocrinology : RB&E·Jin-Juan LiuJia-Yin Liu
Oct 28, 2008·Seminars in Reproductive Medicine·Tannaz ToloubeydokhtiNasser Chegini
Jun 1, 2011·Journal of Assisted Reproduction and Genetics·Scott H Purcell, Kelle H Moley
Jun 21, 2013·Reproductive Biology and Endocrinology : RB&E·Christine DecanterDidier Dewailly
Feb 26, 2016·European Journal of Obstetrics, Gynecology, and Reproductive Biology·Xinyu QiJie Qiao
Nov 30, 2013·Endocrinology and Metabolism Clinics of North America·Anindita Nandi, Leonid Poretsky
Jan 7, 2016·Reproduction : the Official Journal of the Society for the Study of Fertility·Javad RanjbaranIraj Khodadadi
Dec 24, 2015·Journal of Pregnancy·Joselyn RojasValmore Bermúdez
Mar 17, 2016·Systems Biology in Reproductive Medicine·Mahshid SalehabadiIraj Khodadadi
Dec 12, 2012·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Ekaterini KoiouDimitrios Panidis
May 10, 2016·Reproductive Biomedicine Online·Qiong WangCan-Quan Zhou
Jan 1, 2016·Reproduction, Fertility, and Development·Dawit TesfayeKarl Schellander
Mar 3, 2018·Journal of Assisted Reproduction and Genetics·M G Da BroiP A Navarro
Aug 4, 2018·Expert Opinion on Drug Discovery·Romain YvinecFrédérique Clément
Oct 20, 2018·Obesity Reviews : an Official Journal of the International Association for the Study of Obesity·S S LimL J Moran
Jan 10, 2020·Reproductive Sciences·Manuel DobladoAntoni J Duleba
May 27, 2020·Obesity Reviews : an Official Journal of the International Association for the Study of Obesity·Lisa J MoranHelena J Teede
Aug 8, 2020·Endocrine Reviews·Johanne GrosboisIsabelle Demeestere
Aug 14, 2020·The Journal of Clinical Endocrinology and Metabolism·Brittany Y JarrettMarla E Lujan
Jul 18, 2016·Reproductive Biology and Endocrinology : RB&E·V De LeoF Petraglia
Aug 16, 2017·BMC Veterinary Research·Karolina Goździewska-HarłajczukStanisław Dzimira

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.