Implications of Postoperative Complications for Survival After Cytoreductive Surgery and HIPEC: A Multi-Institutional Analysis of the US HIPEC Collaborative.

Annals of Surgical Oncology
Adriana C GamboaCharles A Staley

Abstract

Postoperative complications (POCs) are associated with worse oncologic outcomes in various cancer histologies. The impact of POCs on the survival of patients with appendiceal or colorectal cancer after cytoreductive surgery (CRS) and heated intraperitoneal chemotherapy (HIPEC) is unknown. The US HIPEC Collaborative (2000-2017) was reviewed for patients who underwent CCR0/1 CRS/HIPEC for appendiceal/colorectal cancer. The analysis was stratified by noninvasive appendiceal neoplasm versus invasive appendiceal/colorectal adenocarcinoma. The POCs were grouped into infectious, cardiopulmonary, thromboembolic, and intestinal dysmotility. The primary outcomes were overall survival (OS) and recurrence-free survival (RFS). Of the 1304 patients, 33% had noninvasive appendiceal neoplasm (n = 426), and 67% had invasive appendiceal/colorectal adenocarcinoma (n = 878). In the noninvasive appendiceal cohort, POCs were identified in 55% of the patients (n = 233). The 3-year OS and RFS did not differ between the patients who experienced a complication and those who did not (OS, 94% vs 94%, p = 0.26; RFS, 68% vs 60%, p = 0.15). In the invasive appendiceal/colorectal adenocarcinoma cohort, however, POCs (63%; n = 555) were associated with decreas...Continue Reading

References

Apr 3, 2002·Seminars in Cancer Biology·Nicholas P RestifoChristopher E Touloukian
Dec 31, 2003·Journal of the American College of Surgeons·Nabil P RizkValerie W Rusch
Dec 17, 2010·World Journal of Gastrointestinal Oncology·Tristan D YanStine Munkholm-Larsen
Oct 12, 2016·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·C RaspéP Piso
May 3, 2018·Journal of the National Cancer Institute·Shamgar Ben-Eliyahu, Talia Golan
Dec 12, 2018·The Journal of Surgical Research·Faiz GaniFabian M Johnston

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Citations

May 27, 2021·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·Huseyin AkilliAli Ayhan

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