Abstract
Fixed-dose combination (FDC) prescribing enhances adherence to medication. However, there are limited data regarding the usefulness of FDC drugs across different risk groups. The aim of this study was to explore the relationship between FDC discontinuation and clinical outcomes. From January 2008 to December 2014, patients with FDC prescriptions who visited a cardiology outpatient clinic at a tertiary university hospital in Daegu, Republic of Korea were retrospectively identified. The 10-year atherosclerotic cardiovascular disease (ASCVD) risk score and 20 conventional cardiovascular (CV) risk factors were assessed. Patients were classified according to FDC continuation, together with a tertile of 20 risks. CV events were defined as the composite of admission for worsening heart failure or diabetes, stroke, ischaemic heart disease, and CV death. 502 patients were prescribed with one of the following FDC products: calcium channel blocker (CCB) plus angiotensin receptor blockers (ARB), CCB plus statins, and ARB plus diuretics. During follow-up (mean 2.8±2.4 years), 203 discontinuations (40.4%) occurred. FDC-discontinued patients had lower ASCVD risk scores (24.8% vs. 28.8%, p<0.001), and patients with <6 risk factors discontinued...Continue Reading
References
Apr 20, 2002·Lancet·Taane G ClarkBianca L De Stavola
Oct 7, 2009·Circulation·Giampiero MazzagliaLorenzo G Mantovani
Feb 23, 2010·Journal of General Internal Medicine·Alan J ChristensenGary E Rosenthal
Dec 1, 2007·International Journal of Older People Nursing·Krystyna Cholowski, Robert Cantwell
Sep 3, 2011·American Heart Journal·Hayden B BosworthChristopher B Granger
Jun 23, 2012·Heart Failure Reviews·R Oosterom-CaloJ Brug
Aug 8, 2012·High Blood Pressure & Cardiovascular Prevention : the Official Journal of the Italian Society of Hypertension·Fabio AngeliPaolo Verdecchia
Feb 16, 2013·Current Medicinal Chemistry·A I Wertheimer
Apr 30, 2013·Progress in Cardiovascular Diseases·Ian M Kronish, Siqin Ye
Jul 31, 2013·American Heart Journal·Melvin LafeberFrank L J Visseren
Sep 5, 2013·JAMA : the Journal of the American Medical Association·Simon ThomUNKNOWN UMPIRE Collaborative Group
Nov 30, 2013·European Heart Journal·Salim YusufDenis Xavier
Dec 18, 2013·Journal of Public Health·Kathryn A MurraySusan B Connolly
Feb 5, 2014·Health Psychology : Official Journal of the Division of Health Psychology, American Psychological Association·Derek R Anderson, Charles F Emery
Mar 29, 2014·European Journal of Preventive Cardiology·Anushka PatelUNKNOWN Kanyini Guidelines Adherence with the Polypill (Kanyini GAP) Collaboration
Apr 11, 2014·Clinical Drug Investigation·Peter BramlageRoland E Schmieder
Jun 25, 2014·CMAJ : Canadian Medical Association Journal = Journal De L'Association Medicale Canadienne·Heli HalavaJussi Vahtera
Sep 7, 2014·Journal of the American College of Cardiology·José M CastellanoValentin Fuster
Oct 2, 2015·BMJ Open·Frances WoodHelen Ward
Nov 13, 2015·Expert Opinion on Drug Delivery·Ruth Webster, Anthony Rodgers
Jan 7, 2016·International Journal of Cardiology·Ruth WebsterUNKNOWN SPACE Collaboration
Jan 9, 2016·European Journal of Preventive Cardiology·Melvin LafeberUNKNOWN Programme to Improve Life and Longevity (PILL) Collaborative Group