PMID: 7334401Dec 1, 1981Paper

Implications of the failure of nerve resection and graft to cure chronic pain produced by nerve lesions

Journal of Neurology, Neurosurgery, and Psychiatry
W Noordenbos, P D Wall

Abstract

Seven patients had developed pain and abnormal sensitivity in the area supplied by a single nerve which had been injured. They were treated unsuccessfully for periods ranging from 3 to 108 months by conservative methods including neurolysis, local anaesthesia, sympathetic blocks, guanethidine, transcutaneous stimulation and analgesics. All then had the damaged nerve resected and in five cases a sural nerve graft was inserted to bridge the resected gap. The patients were then examined 20 to 72 months after the operation. In all seven cases pain and abnormal sensitivity of some intensity recurred in the same area and with the same qualitative characteristic as experienced before the operation. This operation should not be done in patients with this condition. Reasons are given to suggest that peripheral nerve damage induces changes in the central nervous system which are not reversed by treatment directed at the area of the original injury.

References

Jan 1, 1978·Progress in Neurobiology·B Csillik, E Knyihár
Jul 1, 1979·Neurology·Z Seltzer, M Devor
Dec 1, 1977·Brain : a Journal of Neurology·P D Wall, W Noordenbos
Jun 20, 1981·The Journal of Comparative Neurology·M Devor, P D Wall
Dec 1, 1980·Cognition·H Hamburger

❮ Previous
Next ❯

Citations

Jan 1, 1990·Acta Neuropathologica·G N FullerR J Guiloff
Jan 17, 2002·Clinical Autonomic Research : Official Journal of the Clinical Autonomic Research Society·J Ochoa, R J Verdugo
Oct 1, 1986·The Journal of Hand Surgery : Journal of the British Society for Surgery of the Hand·A L Dellon, S E Mackinnon
May 10, 2003·Clinics in Plastic Surgery·Adam J VernadakisSusan E Mackinnon
Jan 1, 1997·Anesthesiology·Q H Hogan, S E Abram
Jan 1, 1998·Neuromodulation : Journal of the International Neuromodulation Society·K M AloV Redko
Mar 1, 1984·Journal of Neurology, Neurosurgery, and Psychiatry·T Nurmikko, A Pertovaara
Dec 1, 1984·Postgraduate Medical Journal·C B Parry, R H Withrington
Jan 1, 1989·International Disability Studies·F L Girgis, C B Parry
Mar 13, 2016·Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons·John R Zuniga, David M Yates
Jun 30, 2009·Journal of Plastic, Reconstructive & Aesthetic Surgery : JPRAS·Annemieke StokvisJohan W van Neck
Jan 1, 1993·Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons·J R Zuniga, J P LaBanc
Mar 21, 2007·Colloids and Surfaces. B, Biointerfaces·Xiao-Kun LiXiao-Bing Fu
Nov 6, 2004·Acta Neurologica Scandinavica·R J VerdugoJ L Ochoa
Sep 18, 2007·Pain·C Peter N WatsonChristopher Forrest
Feb 27, 2014·Pain·Marshall Devor, Michael Tal
Feb 1, 1991·Chest·E DajczmanN Wolkove
Jan 27, 2017·Plastic and Reconstructive Surgery·Leahthan F DomeshekSusan E Mackinnon
Feb 1, 1984·The Journal of Hand Surgery : Journal of the British Society for Surgery of the Hand·R H Withrington, C B Wynn Parry
Jun 15, 2012·The Journal of Trauma and Acute Care Surgery·Wolfgang HappakLukas K Kriechbaumer
Jul 23, 2003·International Anesthesiology Clinics·Neeraj KapurAndrew Herlich
May 10, 2002·Annals of the New York Academy of Sciences·R MelzackA L Vaccarino
Aug 30, 2017·Scandinavian Journal of Pain·Per Brodal
Dec 14, 2018·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Louis H Poppler, Susan E Mackinnon
May 18, 2018·Pain·Robert Darrel HelmeTroels Staehelin Jensen
Nov 1, 1995·Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons·J M Gregg

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.