Implications of tryptophan photoproduct FICZ in oxidative stress and terminal differentiation of keratinocytes

Giornale Italiano Di Dermatologia E Venereologia : Organo Ufficiale, Società Italiana Di Dermatologia E Sifilografia
Masutaka FurueGaku Tsuji


Ultraviolet B (UVB) irradiation activates aryl hydrocarbon receptor (AHR), generates reactive oxygen species (ROS) and mediates photocarcinogenesis and photoaging. 6-Formylindolo[3,2-b]carbazole (FICZ) is a tryptophan photoproduct generated by UVB exposure. FICZ exhibits similar biological effects to UVB, including AHR ligation and ROS production. FICZ also acts as a potent photosensitizer for UVA and the production of ROS is synergistically augmented in the simultaneous presence of FICZ and UVA. In contrast, FICZ upregulates the expression of terminal differentiation molecules such as filaggrin and loricrin via AHR. In parallel with this, the administration of FICZ inhibits skin inflammation in a murine psoriasis and dermatitis model. In this article, we summarize the harmful and beneficial aspects of FICZ in skin pathology.


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Dec 11, 2019·International Journal of Environmental Research and Public Health·Masutaka Furue, Gaku Tsuji
Nov 7, 2019·International Journal of Molecular Sciences·Masutaka FurueGaku Tsuji
Jan 16, 2021·International Journal of Molecular Sciences·Masutaka FurueGaku Tsuji
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