Implications of tryptophan photoproduct FICZ in oxidative stress and terminal differentiation of keratinocytes

Giornale Italiano Di Dermatologia E Venereologia : Organo Ufficiale, Società Italiana Di Dermatologia E Sifilografia
Masutaka FurueGaku Tsuji

Abstract

Ultraviolet B (UVB) irradiation activates aryl hydrocarbon receptor (AHR), generates reactive oxygen species (ROS) and mediates photocarcinogenesis and photoaging. 6-Formylindolo[3,2-b]carbazole (FICZ) is a tryptophan photoproduct generated by UVB exposure. FICZ exhibits similar biological effects to UVB, including AHR ligation and ROS production. FICZ also acts as a potent photosensitizer for UVA and the production of ROS is synergistically augmented in the simultaneous presence of FICZ and UVA. In contrast, FICZ upregulates the expression of terminal differentiation molecules such as filaggrin and loricrin via AHR. In parallel with this, the administration of FICZ inhibits skin inflammation in a murine psoriasis and dermatitis model. In this article, we summarize the harmful and beneficial aspects of FICZ in skin pathology.

References

Jan 1, 1997·The Journal of Laboratory and Clinical Medicine·T OhtakeA Hishida
Jan 1, 1997·Journal of Photochemistry and Photobiology. B, Biology·K BenderH J Rahmsdorf
Feb 4, 1998·Biochemical Pharmacology·H ZaherF J Gonzalez
Sep 2, 1998·Proceedings of the National Academy of Sciences of the United States of America·K M Hanson, J D Simon
Jun 8, 1999·Chemico-biological Interactions·Y D WeiA Rannug
Jan 19, 2000·Proceedings of the National Academy of Sciences of the United States of America·Y ShimizuT Ishikawa
Jan 29, 2000·The Journal of Investigative Dermatology·S K KatiyarH Mukhtar
Sep 21, 2000·The Journal of Investigative Dermatology·R GilliesN Kollias
Sep 7, 2001·Toxicology and Applied Pharmacology·J A LoertscherB L Allen-Hoffmann
Aug 2, 2002·Toxicological Sciences : an Official Journal of the Society of Toxicology·Jennifer A LoertscherB Lynn Allen-Hoffmann
Oct 27, 2004·Chemico-biological Interactions·Linda BerganderUlf Rannug
Feb 9, 2006·Photochemical & Photobiological Sciences : Official Journal of the European Photochemistry Association and the European Society for Photobiology·Georg T WondrakElaine L Jacobson
Nov 17, 2006·The Journal of Investigative Dermatology·David R Bickers, Mohammad Athar
Mar 17, 2007·The Journal of Investigative Dermatology·Jürgen BaierWolfgang Bäumler
May 16, 2007·Proceedings of the National Academy of Sciences of the United States of America·Ellen FritscheJean Krutmann
Dec 14, 2007·Chemical Research in Toxicology·Linh P Nguyen, Christopher A Bradfield
Mar 4, 2009·Proceedings of the National Academy of Sciences of the United States of America·Carrie Hayes SutterThomas R Sutter
Jun 18, 2009·BMC Cancer·Vasilis P AndroutsopoulosDemetrios A Spandidos
Sep 28, 2010·Biological Chemistry·Josef Abel, Thomas Haarmann-Stemmann
Aug 13, 2011·Toxicological Sciences : an Official Journal of the Society of Toxicology·Carrie Hayes SutterThomas R Sutter
Mar 7, 2012·Proceedings of the National Academy of Sciences of the United States of America·Emma WincentAgneta Rannug
Mar 13, 2012·Journal of the American Academy of Dermatology·Lucy ChenSteven Q Wang
Nov 16, 2012·Toxicological Sciences : an Official Journal of the Society of Toxicology·Lawrence H KennedyThomas R Sutter
Jan 26, 2013·The Journal of Clinical Investigation·Ellen H van den BogaardJoost Schalkwijk
Mar 2, 2013·The Journal of Investigative Dermatology·Prokopios MagiatisIoannis D Bassukas
Aug 21, 2013·Seminars in Immunopathology·Charlotte EsserJean Krutmann
Mar 25, 2014·Annual Review of Immunology·Brigitta StockingerJoão H Duarte
Jun 27, 2014·Archives of Dermatological Research·Masutaka FurueHiroshi Uchi
Sep 27, 2014·Biochemistry & Pharmacology : Open Access·Joann B Powell, Maryam Ghotbaddini
Jan 21, 2015·The Journal of Investigative Dermatology·Ellen H van den BogaardAdam B Glick
Feb 7, 2015·Pharmacological Reviews·Charlotte Esser, Agneta Rannug
Feb 15, 2015·Toxicology Letters·Kenjiro TakeiMasutaka Furue

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Citations

Dec 11, 2019·International Journal of Environmental Research and Public Health·Masutaka Furue, Gaku Tsuji
Nov 7, 2019·International Journal of Molecular Sciences·Masutaka FurueGaku Tsuji
Jan 16, 2021·International Journal of Molecular Sciences·Masutaka FurueGaku Tsuji
May 27, 2021·Journal of Biochemical and Molecular Toxicology·Hamidreza MohammadiAfshin Mohammadi-Bardbori

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