PMID: 9526704Apr 4, 1998Paper

Implications of using follicle-stimulating hormone preparations depleted of luteinizing hormone to achieve follicular growth in in vitro fertilization

Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology
R AgrawalH S Jacobs

Abstract

We aimed to compare the outcome of in vitro fertilization (IVF) treatment using follicle-stimulating hormone (FSH) containing gonadotropins with human menopausal gonadotropin (hMG) containing gonadotropins for ovarian stimulation. A retrospective analysis of 82 patients undergoing IVF in a private fertility clinic was performed over a specific period of time. Eighteen women received hMG, 20 received Normegon and 44 received FSH. In addition, 17 of these patients received hMG in one cycle and FSH in the other. The main outcome measures studied were duration of treatment, dose of gonadotropins required to achieve optimum follicular growth, number and size of follicles, endometrial thickness, serum estradiol concentrations, number of oocytes retrieved, pregnancy rates and the incidence of ovarian hyperstimulation syndrome (OHSS). At the time of administration of human chorionic gonadotropin (hCG), the mean (+/- SD) serum estradiol concentrations in patients treated with preparations containing FSH and luteinizing hormone (LH) in a ratio of 1:1 was 10,044.3 +/- 5378.8 pmol/l compared with 6819.5 +/- 2597.9 pmol/l in patients treated with preparations with FSH and LH in a ratio of 3:1 and 7369 +/- 4300 pmol/l in patients treated wit...Continue Reading

References

Sep 1, 1978·Fertility and Sterility·J G Schenker, D Weinstein
Oct 1, 1988·Human Reproduction·K DiedrichD Krebs

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Citations

Sep 7, 2002·Fertility and Sterility·UNKNOWN European and Israeli Study Group on Highly Purified Menotropin versus Recombinant Follicle-Stimulating Hormone
Nov 5, 2002·Fertility and Sterility·Helmy A SelmanImam El-Danasouri
Aug 2, 2003·Trends in Endocrinology and Metabolism : TEM·Marco FilicoriSilvia Bernardi
Oct 12, 2013·Molecular Human Reproduction·Stephen G Hillier
Apr 25, 2001·Journal of Psychosomatic Obstetrics and Gynaecology·G A Schuiling
Aug 9, 2013·Developmental Neurorehabilitation·Stefan NilssonSara Hvit

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