Implications on cerebellar function from information coding.

The Cerebellum
Chi-ming Huang

Abstract

One function of the cerebellar cortex is to process information. There are at least two types of information. Temporal information is encoded in the timing pattern of action and synaptic potentials, whereas structural information is encoded in the spatial pattern of the cerebellar synaptic circuitry. Intuitively, analysis of highly complex information in the time domain would require a cerebellar cortex with structural complexity to match. Information theory offers a way to estimate quantitatively both types of information and thereby helps to test hypotheses or advance theories of cerebellar neurobiology. These estimates suggest: (i) That the mossy-fiber-granule-cell system carries far more (temporal) information than the climbing fiber system, (ii) that Purkinje cells extract only a fraction of the (temporal) information from their afferents, and (iii) that the cerebellar cortex has a large (spatial) information coding capacity. Concerning information, one can argue that the cerebellar cortex analyzes temporal information in its afferents as a search engine, in search of coincidental mossy fiber events based on timing cues provided by climbing fiber events. Results of successive searches are continuously being converted into ...Continue Reading

References

Apr 1, 1979·The Journal of Physiology·D M Armstrong, J A Rawson
Dec 22, 1992·The Journal of Comparative Neurology·B B AndersenB Pakkenberg
Jan 1, 1992·Annual Review of Neuroscience·W T ThachJ G Keating
Jan 1, 1991·Progress in Neurobiology·R J Harvey, R M Napper
Aug 8, 1988·The Journal of Comparative Neurology·R J Harvey, R M Napper
Aug 8, 1988·The Journal of Comparative Neurology·R M Napper, R J Harvey
Aug 8, 1988·The Journal of Comparative Neurology·R M Napper, R J Harvey
Apr 16, 1986·Brain Research·C M Huang, R Burkard
Nov 1, 1974·Journal of Neurocytology·V Chan-PalayS M Billings-Gagliardi
Jun 1, 1969·The Journal of Physiology·D Marr
Jan 1, 1994·Journal of Neurophysiology·E De Schutter, J M Bower
May 24, 1994·Proceedings of the National Academy of Sciences of the United States of America·E De Schutter, J M Bower
Jun 1, 1997·The Behavioral and Brain Sciences·V BraitenbergF Sultan
May 26, 1999·The Journal of Comparative Neurology·G Gundappa-SulurJ M Bower
Jun 17, 1999·Trends in Neurosciences·G T Buracas, T D Albright
Oct 13, 1999·Brain Research·C M HuangR H Huang
Apr 25, 2002·Proceedings of the National Academy of Sciences of the United States of America·Gordon M G ShepherdPer Andersen
Sep 18, 2002·Proceedings of the National Academy of Sciences of the United States of America·Jeffrey A KleimDrew Walters
Oct 26, 2002·Neuroscience Letters·Kara D FedermeierWilliam T Greenough
Nov 5, 2002·Nature Reviews. Neuroscience·Masao Ito
Apr 12, 2003·Trends in Neurosciences·Tatsuya OhyamaMichael D Mauk
Jul 30, 2003·Scientific American·James M Bower, Lawrence M Parsons
Feb 1, 1958·The Journal of Comparative Neurology·V BRAITENBERG, R P ATWOOD
Oct 14, 2003·The Journal of Comparative Neurology·Birgitte Bo AndersenBente Pakkenberg
Dec 5, 2003·Progress in Brain Research·James R Bloedel
Apr 23, 2004·Nature·Paul ChaddertonMichael Häusser
Sep 21, 2004·The Journal of Neuropsychiatry and Clinical Neurosciences·Jeremy D Schmahmann
Dec 23, 2004·The Journal of Physiology·Wolfgang MittmannMichael Häusser
Mar 25, 2005·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Robert E Sims, Nicholas A Hartell

❮ Previous
Next ❯

Citations

Feb 11, 2010·The Cerebellum·Mario Manto, Nordeyn Oulad Ben Taib
Nov 27, 2010·The Cerebellum·Martin BaresJames Ashe
Dec 15, 2010·Schizophrenia Bulletin·Jennifer K ForsythWilliam P Hetrick
Jun 23, 2009·Neuropeptides·Peter Kovacs, Andras Hajnal
Jun 29, 2010·Journal of Anatomy·Richard Ewald RoschJennifer Mary Gurd
Mar 7, 2009·Journal of Gerontological Nursing·Meredith Flood, Kathleen C Buckwalter
Aug 21, 2021·Neuroscience and Biobehavioral Reviews·E J TehovnikA S Tolias

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

© 2022 Meta ULC. All rights reserved