PMID: 3320052Dec 1, 1987Paper

Import of fructose bisphosphate aldolase into the glycosomes of Trypanosoma brucei

The Journal of Cell Biology
C E Clayton

Abstract

The glycolytic enzymes of Trypanosomatids are compartmentalized within peroxisome-like microbodies called glycosomes. Fructose bisphosphate aldolase is synthesized on free polysomes and imported into glycosomes within 5 min. Peptide mapping reveals no primary structural differences between the in vivo-synthesized protein and that made in vitro from a synthetic template. However, native aldolase from glycosomes is partially protease resistant, whereas the in vitro translation product is not. Pulse-chase results indicate that aldolase in bloodstream trypanosomes has a much longer half-life than in the procyclic tsetse fly form.

References

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Citations

Apr 1, 1994·Journal of Bioenergetics and Biomembranes·V Hannaert, P A Michels
Feb 1, 1989·Molecular and Biochemical Parasitology·C E Clayton, J A Fox
Apr 1, 1991·Molecular and Biochemical Parasitology·K Fung, C Clayton
Feb 1, 1996·Molecular and Biochemical Parasitology·T Häusler, C Clayton
Nov 6, 2003·Molecular and Biochemical Parasitology·Susanne BiebingerChristine Clayton
Jul 11, 2002·Molecular and Biochemical Parasitology·Arun PalMark C Field
Mar 22, 2001·Molecular Microbiology·A MaierC Clayton
Mar 6, 1995·FEBS Letters·J BlattnerC E Clatyon
Mar 16, 2016·Molecular and Biochemical Parasitology·Mariana BonillaMarcelo A Comini
Oct 1, 1989·Experimental Parasitology·P A Michels
Nov 13, 2004·FEMS Microbiology Reviews·Juliette MoyersoenPaul A M Michels
Oct 21, 2006·Molecular and Biochemical Parasitology·Van-Duc LuuChristine Clayton
Dec 6, 2014·Molecular and Biochemical Parasitology·Jurgen R HaanstraPaul A M Michels
Dec 1, 2006·Advances in Parasitology·Michael P Barrett, Ian H Gilbert
Jan 9, 2015·PLoS Neglected Tropical Diseases·Inês LoureiroJoana Tavares
Sep 27, 2018·PLoS Pathogens·Daniela BegoloChristine Clayton
Dec 18, 2013·PLoS Neglected Tropical Diseases·Inês LoureiroAnabela Cordeiro-da-Silva
Oct 3, 2018·PLoS Neglected Tropical Diseases·Chaitali Chakraborty, Christine Clayton
Jul 16, 2004·The Journal of Biological Chemistry·Zhifeng ZhengKojo Mensa-Wilmot
Mar 31, 2021·ELife·Larissa Melo do NascimentoEsteban Erben
Sep 1, 1995·Microbiological Reviews·C ClaytonJ Blattner
Oct 1, 1988·Molecular and Cellular Biology·M R Mowatt, C E Clayton
Jun 1, 1990·Molecular and Cellular Biology·C E ClaytonM R Mowatt
Jun 1, 1989·Biochimica Et Biophysica Acta·P Borst

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