Importance in diagnosis of gastritis of detection by PCR of the cagA gene in Helicobacter pylori strains isolated from children.

Journal of Clinical Microbiology
M O HussonH Leclerc

Abstract

The cagA gene has been detected by PCR and DNA hybridization in 45 Helicobacter pylori strains isolated from children. For each child, clinical symptoms, endoscopic aspect of the gastric mucosa, and histological gastritis were evaluated. Gene-positive strains were associated with hemorrhagic gastritis in 66.6% of the children, while gene-negative strains were associated with hemorrhagic gastritis in 11.2% of the children (P = 0.0001). In addition, 88.8% of gene-positive strains were associated with severe histological gastritis (scores of 3 and 4), and gene-negative strains were collected from the gastric mucosa with the same type of infiltration of neutrophils and lymphocytes in the lamina propia in 55.5% of the children. These differences were statistically significant (P = 0.017). Gene-positive strains were also isolated more frequently from children with vomiting (P = 0.04), while the absence of clinical signs was not significantly different in cagA gene-positive or -negative patients. All of these observations confirmed the role of this cagA gene as a marker of gastric inflammation in children. The detection of this gene might be helpful to determine the degree of inflammation of the gastric mucosa in the absence of abdomi...Continue Reading

References

Aug 1, 1992·Journal of Clinical Pathology·J E CrabtreeD S Tompkins
Oct 1, 1992·Molecular Microbiology·H LeyingR Haas
Dec 7, 1989·The New England Journal of Medicine·C P DooleyM J Blaser
Jan 1, 1972·Journal of Clinical Pathology·R WhiteheadM W Gear
Feb 1, 1994·Journal of Clinical Microbiology·J RaymondC Dupont
Oct 1, 1993·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·Z XiangD Armellini
Jun 15, 1993·Proceedings of the National Academy of Sciences of the United States of America·A CovacciN Figura

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Citations

Dec 1, 1998·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·M LoebP Sherman
Oct 23, 2002·Helicobacter·Hans-Jürg Monstein, Katarina Ellnebo-Svedlund
Apr 17, 2004·Journal of Gastroenterology and Hepatology·Alexander A Nijevitch, Peter L Shcherbakov
Sep 9, 1999·Journal of Clinical Gastroenterology·Y ElitsurC Neace
Feb 18, 1999·The American Journal of Gastroenterology·Y Elitsur
Jan 16, 1999·Journal of Pediatric Gastroenterology and Nutrition·H M MitchellY Y Li
Oct 29, 2003·Journal of Pediatric Gastroenterology and Nutrition·Paul R HarrisGuillermo Perez-Perez
Sep 12, 2002·BMC Gastroenterology·Gustavo FaundezGuillermo Figueroa
Sep 3, 2002·Clinical and Diagnostic Laboratory Immunology·Günter BodeHermann Brenner
May 1, 1999·The Pediatric Infectious Disease Journal·K L KolhoH Rautelin
Jul 2, 2005·Journal of Pediatric Gastroenterology and Nutrition·Ylva TindbergMarta Granström
Dec 30, 2009·Journal of Pediatric Gastroenterology and Nutrition·James R RickAndre Dubois
Oct 30, 2013·Helicobacter·Eugenia MendozaXimena Duque
Mar 6, 1999·Journal of Pediatric Gastroenterology and Nutrition·K OksanenM Ashorn
Jul 1, 1997·Journal of Pediatric Gastroenterology and Nutrition·F GottrandJ P Farriaux
Feb 17, 2001·Archives of Medical Research·J TorresO Muñoz
Jun 12, 1999·Journal of Clinical Microbiology·L J van DoornW G Quint
Jan 5, 2000·Journal of Clinical Microbiology·S KatoM J Blaser

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