PMID: 9181232Jun 1, 1997Paper

Importance of a new tumor marker TRA-1-60 in the follow-up of patients with clinical stage I nonseminomatous testicular germ cell tumors

Annals of Surgical Oncology
M E GelsH Schraffordt Koops

Abstract

TRA-1-60 is a new tumor marker for embryonal carcinoma-positive nonseminomatous testicular germ cell tumors (NSTGCT). Upper normal reference value (RV) and serum half-life (t1/2) were determined. The value was determined in the follow-up of 154 patients with stage I NSTGCT. TRA-1-60 was measured in normal controls (n = 100) to determine RV and in patients without recurrence for t1/2. In all patients, TRA-1-60 was determined at the time of orchidectomy. In 42 patients with recurrence, values were also evaluated 1 month before and at the time of computed tomography-confirmed recurrence. Predictive values and survival probability were examined and compared with values for alpha-fetoprotein (AFP) and human chorionic gonadotropin (hCG). RV was 230 U/ml and t1/2 9.5 days. Elevated TRA-1-60 at the time of orchidectomy was not associated with recurrence. One month before recurrence, 21 of 42 patients had elevated TRA-1-60 levels (50%); 10 were negative for both AFP and hCG. At the time of recurrence, 24 patients had elevated TRA-1-60 levels (57.1%): 9 were negative for AFP/hCG. Patients with TRA-1-60 levels of > 500 U/ml had a poorer recurrence-free survival probability (p = 0.015). TRA-1-60 is useful in the follow-up of stage 1 NSTGCT...Continue Reading

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Citations

Mar 14, 2003·European Journal of Nuclear Medicine and Molecular Imaging·U LassenM Rørth
Mar 12, 2020·Nature Reviews. Urology·Kristian AlmstrupKlaus-Peter Dieckmann
Jul 13, 2002·International Journal of Cancer. Journal International Du Cancer·Henrik LajerNiels Erik Skakkebaek
Apr 4, 2021·International Journal of Molecular Sciences·João LoboRui Henrique
Dec 31, 2002·Biochemical and Biophysical Research Communications·W Michael SchopperleWilliam C DeWolf
Aug 1, 1997·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·J P van BastenH J Hoekstra

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