PMID: 8941504Nov 1, 1996Paper

Importance of airway blood flow on particle clearance from the lung

Journal of Applied Physiology
E M Wagner, W M Foster

Abstract

The role of the airway circulation in supporting mucociliary function has been essentially unstudied. We evaluated the airway clearance of inert, insoluble particles in anesthetized ventilated sheep (n = 8), in which bronchial perfusion was controlled, to determine whether airway mucosal blood flow is essential for maintaining surface transport of particles through airways. The bronchial branch of the bronchoesophageal artery was cannulated and perfused with autologous blood at control flow (0.6 ml.min-1.kg-1) or perfusion was stopped. With the sheep in a supine position and after a steady-state 133Xe ventilation scan for designation of lung zones of interest, an inert 99mTc-labeled sulfur colloid aerosol (2.1-microns diameter) was deposited in the lung. The clearance kinetics of the radiolabeled particles were determined from the activity-time data obtained for right and left lung zones. At 60 min postdeposition of aerosol, average airway particle retention for control bronchial blood flow conditions was 57 +/- 7 (SE)% for the right and 53 +/- 8% for the left lung zones. Clearance of particles was significantly impaired when bronchial blood flow was stopped, e.g., right and left lung zones averaged 77 +/- 6 and 76 +/- 7% at 60...Continue Reading

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Citations

Sep 7, 2001·Environmental Health Perspectives·E M Wagner, W M Foster
Aug 21, 2010·Journal of Applied Physiology·Stuart B MazzoneBrendan J Canning
May 4, 2012·Surgical and Radiologic Anatomy : SRA·Stephen OsiroMarios Loukas
Feb 22, 2001·Journal of Applied Physiology·W M FosterL M Miller
Jul 29, 2009·Toxicological Sciences : an Official Journal of the Society of Toxicology·Rajiv K SaxenaUrmila P Kodavanti
Aug 22, 2014·Current Opinion in Organ Transplantation·Michael Z TongGosta B Pettersson
Mar 27, 2010·American Journal of Respiratory and Critical Care Medicine·Gundeep S DhillonMark R Nicolls
Aug 7, 2010·Current Opinion in Organ Transplantation·Mark R Nicolls, Martin R Zamora
Jul 11, 2018·Multidisciplinary Respiratory Medicine·Alison Pieterse, Susan D Hanekom
Mar 15, 2001·Journal of Applied Physiology·E M Wagner, W M Foster
Nov 22, 2001·Journal of Applied Physiology·W M Foster, E M Wagner
Sep 9, 2006·Journal of Applied Physiology·Maurizio MeineroVito Brusasco

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