Importance of Angiogenin and Endothelial Progenitor Cells After Rehabilitation Both in Ischemic Stroke Patients and in a Mouse Model of Cerebral Ischemia

Frontiers in Neurology
Marina Gabriel-SalazarAnna Rosell

Abstract

Background: Rehabilitation therapy is the only available treatment for stroke survivors presenting neurological deficits; however, the underlying molecules and mechanisms associated with functional/motor improvement during rehabilitation are poorly understood. Objective: Our aim is to study the modulation of angiogenin and endothelial progenitor cells (EPCs) as repair-associated factors in a cohort of stroke patients and mouse models of rehabilitation after cerebral ischemia. Methods: The clinical study included 18 ischemic strokes admitted to an intensive rehabilitation therapy (IRT) unit, 18 non-ischemic controls and brain samples from three deceased patients. Angiogenin and EPCs were measured in blood obtained before and up to 6 months after IRT together with an extensive evaluation of the motor/functional status. In parallel, C57BL/6 mice underwent middle cerebral artery occlusion, and the pasta matrix reaching-task or treadmill exercises were used as rehabilitation models. Angiogenin RNA expression was measured after 2 or 12 days of treatment together with cell counts from EPCs cultures. Results: Brain angiogenin was identified in both human and mouse tissue, whereas serum levels increased after 1 month of IRT in associati...Continue Reading

References

Feb 7, 2003·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Takeshi HayashiPak H Chan
Aug 3, 2004·The Journal of Clinical Investigation·Akihiko TaguchiTomohiro Matsuyama
Sep 12, 2006·Journal of Thrombosis and Haemostasis : JTH·A Tello-MontoliuG Y H Lip
Sep 15, 2006·Proceedings of the National Academy of Sciences of the United States of America·Norie YoshiokaGuo-fu Hu
Oct 3, 2007·Archives of Physical Medicine and Rehabilitation·Jan MehrholzMarcus Pohl
Nov 6, 2007·European Heart Journal·Antonio Tello-MontoliuGregory Y H Lip
Feb 26, 2008·Archives of Physical Medicine and Rehabilitation·Robert W TeasellJeffrey W Jutai
May 9, 2008·Journal of Neurologic Physical Therapy : JNPT·George D Fulk, John L Echternach
Jan 23, 2009·Annals of Medicine·Jeetesh V PatelGregory Y H Lip
May 16, 2009·Cell Death and Differentiation·J SebastiàJ H M Prehn
Aug 12, 2009·Journal of the Neurological Sciences·Li HuangHuailian Guo
May 17, 2011·Lancet·Peter LanghorneGert Kwakkel
Aug 2, 2011·Current Cardiology Reviews·M Angels FontJerzy Krupinski
Feb 1, 2012·Neuropathology and Applied Neurobiology·Anna MoranchoAnna Rosell
May 24, 2012·Stroke; a Journal of Cerebral Circulation·Adviye ErgulSusan C Fagan
Aug 28, 2012·Stroke; a Journal of Cerebral Circulation·Marcela PeknaMichael Nilsson
Jan 10, 2013·Current Neurology and Neuroscience Reports·Erin Burke, Steven C Cramer
Apr 30, 2013·Journal of Neuroengineering and Rehabilitation·Pengyue ZhangYongshan Hu
Aug 10, 2013·Annals of Neurology·Aaron W Grossman, Joseph P Broderick
Dec 24, 2013·Brain and Behavior·Joan Martí-FàbregasLina Badimon
Jul 25, 2014·Neurorehabilitation and Neural Repair·Jakob Udby BlicherYi-Ching Lynn Ho
Oct 22, 2014·Expert Review of Neurotherapeutics·Robert TeasellStephen Page
Apr 18, 2015·The New England Journal of Medicine·Tudor G JovinUNKNOWN REVASCAT Trial Investigators
May 23, 2015·Stem Cell Research & Therapy·Monika RabensteinMaria Adele Rueger
Dec 26, 2015·Acta Biochimica Et Biophysica Sinica·Jinghao Sheng, Zhengping Xu
Oct 27, 2016·Archives of Physical Medicine and Rehabilitation·Feifei MaAnna Rosell
Jan 27, 2017·Circulation·Emelia J BenjaminUNKNOWN American Heart Association Statistics Committee and Stroke Statistics Subcommittee
Jul 13, 2017·International Journal of Stroke : Official Journal of the International Stroke Society·Marion F WalkerCaroline L Watkins
Jul 13, 2017·International Journal of Stroke : Official Journal of the International Stroke Society·Lara A BoydSteven C Cramer

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Citations

Jan 12, 2019·Neural Regeneration Research·Hong-Ying LiKwok-Fai So
Aug 23, 2018·American Journal of Physiology. Cell Physiology·Gema EsquivaAnna Rosell
Apr 6, 2021·Frontiers in Physiology·Venkatagiri KrishnamurthyJoe R Nocera
Jul 9, 2021·Frontiers in Neurology·Marina Gabriel-SalazarAnna Rosell
Jul 4, 2021·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Ji LiDa-Wei Li
Dec 14, 2021·Frontiers in Neurology·Nicolás Garcia-RodriguezAnna Rosell

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Methods Mentioned

BETA
ELISA
FCS
density gradient centrifugation
Assay
PCR

Software Mentioned

ImageJ
FCS

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