PMID: 2105897Feb 1, 1990Paper

Importance of catecholamine release for the functional action of intrastriatal implants of adrenal medullary cells: pharmacological analysis and in vivo electrochemistry

Experimental Neurology
R DecombeJ P Herman

Abstract

The aim of the present experiments was to test whether adrenal chromaffin cells implanted into the striatum of rats could exert a functional effect through a release of catecholamines. A cell suspension obtained from bovine adrenal medulla was implanted unilaterally into the striatum. The striatal dopaminergic input was extensively destroyed beforehand to preclude the possibility of reinnervation of the striatum by endogenous dopaminergic neurons. The functional influence of the implant was tested through the measurement of drug-induced rotation, while catecholamine release was measured subsequently in the same animals by in vivo electrochemistry. Transplant survival, as shown by the immunohistochemical analysis performed at the end of the in vivo experiments, was highly variable. Surviving chromaffin cells maintained their endocrine morphology and no reinnervation of the host striatum could be detected. Rotation of the animals evoked by apomorphine (0.1 mg/kg, sc) or amphetamine (5.0 mg/kg, ip) following the lesion was left uninfluenced following transplantation, even when a large transplant was recovered. On the other hand, nicotine (0.5 mg/kg, sc) evoked a strong contraversive rotational response in the transplant-bearing an...Continue Reading

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Citations

Mar 1, 1991·Journal of Cellular Biochemistry·W J FreedE I Ginns
Aug 1, 1991·Trends in Neurosciences·A Björklund
Nov 1, 1995·Neurobiology of Aging·J L Mendoza-RamírezR Drucker-Colín
Sep 1, 1994·Progress in Neurobiology·J P Herman, N D Abrous
Feb 1, 1997·Brain Research. Molecular Brain Research·F LisovoskiM Peschanski
Nov 1, 1990·Experimental Neurology·W J FreedJ B Becker
Jan 1, 1992·Neuroscience and Biobehavioral Reviews·D F EmerichP R Sanberg
Jan 1, 1993·Reviews in the Neurosciences·C GagnonT Di Paolo
Apr 1, 1993·Reviews in the Neurosciences·R Barker, S Dunnett

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