Importance of CMR within the Task Force Criteria for the diagnosis of ARVC in children and adolescents

Journal of the American College of Cardiology
Yousef EtoomLars Grosse-Wortmann

Abstract

Cardiac magnetic resonance (CMR) is a component of the revised Task Force Criteria (rTFC) for the diagnosis of arrhythmogenic right ventricular cardiomyopathy (ARVC). However, its diagnostic value in a pediatric population is unknown. This study examined the contribution of CMR to diagnosing ARVC using the rTFC in a pediatric population. Clinical CMR studies of 142 pediatric patients evaluated for ARVC between 2005 and 2009 were reviewed. Patients were categorized into "definitive," "borderline," "possible," or "no" ARVC diagnostic groups based on the rTFC. The extent to which each element of the rTFC contributed to diagnosing ARVC was determined using a c-statistics model. A total of 23 (16%), 32 (23%), 37 (26%), and 50 (35%) patients had definite, borderline, possible, and no ARVC, respectively, applying the rTFC. The prevalence of regional wall motion abnormalities in these groups was 83%, 53%, 22%, and 16%, respectively (p < 0.001). By CMR, right ventricular end-diastolic volumes were 118 ± 31 cc/m², 108 ± 22 cc/m², 94 ± 14 cc/m², and 92 ± 18 cc/m², respectively (p < 0.001). Right ventricular fatty infiltration and fibrosis were detected in only 1 and 3 patients, respectively, all of whom had definitive ARVC. Of all rTFC ma...Continue Reading

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Citations

Mar 15, 2015·Journal of the American College of Cardiology·Tal Geva
Jan 5, 2017·The New England Journal of Medicine·Domenico CorradoHugh Calkins
Jan 1, 2016·Pediatric Radiology·Maryam EtesamiPrabhakar Rajiah
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Nov 28, 2017·Cardiac Electrophysiology Clinics·Gourg Atteya, Rachel Lampert
May 8, 2021·Current Cardiology Reports·Chrysanthos Grigoratos, Giovanni Donato Aquaro

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