Importance of complement source in bactericidal activity of human antibody and murine monoclonal antibody to meningococcal group B polysaccharide.

Infection and Immunity
Wendell D Zollinger, R Mandrell

Abstract

The bactericidal activity of human antibody and murine monoclonal antibody to meningococcal group B polysaccharide was investigated as a function of the complement source. The immunoglobulin M murine monoclonal antibody 2-2-B was shown by several different methods to be highly specific for meningococcal group B and Escherichia coli K1 capsular polysaccharides. It had strong bactericidal activity in conjunction with either rabbit or human complement, but gave a higher titer with rabbit complement. A strong prozone was observed in each case. Human postvaccination antibody to meningococcal group B polysaccharide was strongly bactericidal with rabbit complement, but had little or no bactericidal activity in conjunction with human complement. Antibodies in adult normal human sera that were bactericidal with rabbit complement were also found to be predominantly directed against the meningococcal group B capsular polysaccharide. Human antibodies that were bactericidal with human complement appeared to be primarily directed against noncapsular antigens.

Citations

Jan 1, 1989·Scandinavian Journal of Infectious Diseases·A HalstensenC O Solberg
Apr 7, 1997·The Journal of Experimental Medicine·D MartinB R Brodeur
Mar 29, 2000·The Journal of Biological Chemistry·J McLeod GriffissW Zollinger
Feb 6, 2004·Expert Review of Vaccines·Paul Balmer, Ray Borrow
Mar 3, 2009·Expert Review of Vaccines·Ray Borrow, Jamie Findlow
May 28, 2011·Expert Opinion on Biological Therapy·Xilian BaiRay Borrow
Sep 17, 2011·Expert Review of Vaccines·Donatella PanattoRoberto Gasparini
Mar 14, 2014·Clinical and Vaccine Immunology : CVI·Mary Adetinuke BoydMyron M Levine
Oct 1, 1984·European Journal of Clinical Microbiology·R A Polin
Aug 1, 1990·Scandinavian Journal of Immunology·J W LarrickJ V Gavilondo-Cowley
Jan 5, 2002·Clinical and Diagnostic Laboratory Immunology·Tamara RodríguezOliver Pérez
May 15, 2007·Clinical and Vaccine Immunology : CVI·Caroline TrotterRay Borrow
Oct 16, 2009·Clinical and Vaccine Immunology : CVI·Wendell D ZollingerDeborah H Schmiel
Nov 11, 2015·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Gregory A PriceMargaret C Bash
Dec 15, 2015·Expert Review of Vaccines·Volker VetterRay Borrow
Jan 1, 1987·Antonie van Leeuwenhoek·W D ZollingerB L Brandt
Oct 29, 2005·Scandinavian Journal of Immunology·H TiwanaB M Charalambous
Apr 30, 2003·The Journal of Biological Chemistry·Lucy Vandeputte-RuttenPiet Gros
May 1, 2007·The Pediatric Infectious Disease Journal·Oleg BilukhaMarc Fischer
Aug 12, 2003·Expert Review of Vaccines·Delia Bethell, Andrew J Pollard
Sep 21, 2017·Glycoconjugate Journal·Renata Chagas BastosIvna Alana Freitas Brasileiro da Silveira
Mar 4, 2020·Postgraduate Medicine·Paul BalmerAmit Srivastava
Jan 1, 1991·Transactions of the Royal Society of Tropical Medicine and Hygiene·W D Zollinger, E Moran
Jan 1, 1990·Scandinavian Journal of Infectious Diseases. Supplementum·M A Salih
May 1, 2001·Clinical and Diagnostic Laboratory Immunology·G F SantosD M Granoff
Apr 27, 2000·The Pediatric Infectious Disease Journal·A J Pollard, M Levin
Feb 23, 2008·The Journal of Immunology : Official Journal of the American Association of Immunologists·Jutamas NgampasutadolPeter A Rice
Apr 22, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·Jo Anne WelschDan M Granoff
Sep 2, 2004·Paediatric Drugs·Jens U Rüggeberg, Andrew J Pollard

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antibody Specificity

Antibodies produced by B cells are highly specific for antigen as a result of random gene recombination and somatic hypermutation and affinity maturation. As the main effector of the humoral immune system, antibodies can neutralize foreign cells. Find the latest research on antibody specificity here.