Importance of continuous sequential chemotherapy and multimodal treatment for advanced testicular cancer: a high-volume Japanese center experience

Medicine
Terukazu NakamuraTsuneharu Miki

Abstract

Patients with "difficult-to-treat" advanced testicular cancer can require multiple therapies. We retrospectively assessed our patients with advanced germ cell tumors (GCTs) and characterized the clinical efficacy, outcomes, and factors affecting overall survival (OS).Two hundred fifty-three patients with advanced GCTs were treated at Kyoto Prefectural University of Medicine, Kyoto, Japan, from June 1998 to September 2013. Of 253 patients, 142 patients had salvage chemotherapy.As first-line therapy, bleomycin, etoposide, and cisplatin, and etoposide and cisplatin therapies were performed in 234 cases (92.5%). As second-line therapy, etoposide, ifosfamide, and cisplatin/vinblastine, ifosfamide, and cisplatin, and paclitaxel, ifosfamide, and cisplatin/paclitaxel, ifosfamide, and nedaplatin therapies were carried out in 44 and 59 cases, respectively. Furthermore, 111, 72, 44, and 28 cases had third, fourth, fifth, and sixth-or-later-line chemotherapy, respectively. Five-year OS rate stratified by chemotherapy line was 95.5% in the first line, 89.4% in the second line, 82.1% in the third line, 45.1% in the fourth line, and 58.9% in the fifth or after line. A statistical significant difference was found when comparing fourth-or-after...Continue Reading

References

Jul 17, 1998·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·P J LoehrerL H Einhorn
Mar 15, 2000·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·P PorcuL H Einhorn
Jun 16, 2000·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·R J MotzerG J Bosl
Aug 30, 2003·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Jan OldenburgSophie D Fossa
Jun 2, 2005·Annals of Oncology : Official Journal of the European Society for Medical Oncology·J-L PicoUNKNOWN European Group for Blood and Marrow Transplantation (EBMT)
Mar 16, 2007·Annals of Oncology : Official Journal of the European Society for Medical Oncology·J ShamashT Oliver
Jun 27, 2007·International Journal of Urology : Official Journal of the Japanese Urological Association·Norio NonomuraAkihiko Okuyama
Jul 3, 2007·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Anja LorchUNKNOWN German Testicular Cancer Study Group
Mar 30, 2011·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Anja LorchJörg Beyer
Apr 13, 2011·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Sven-Erik OlofssonEva Cavallin-Ståhl
May 25, 2012·Current Treatment Options in Oncology·Sukaina RashidThomas Powles
Jul 19, 2013·Annals of Oncology : Official Journal of the European Society for Medical Oncology·A NecchiR Salvioni
Oct 23, 2013·Annals of Oncology : Official Journal of the European Society for Medical Oncology·J OldenburgUNKNOWN ESMO Guidelines Working Group

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Citations

Jul 18, 2018·International Journal of Urology : Official Journal of the Japanese Urological Association·Takumi ShiraishiUNKNOWN Cancer Registration Committee of the Japanese Urological Association
May 13, 2018·International Journal of Urology : Official Journal of the Japanese Urological Association·Yuta InoueOsamu Ukimura
Jun 5, 2021·International Journal of Urology : Official Journal of the Japanese Urological Association·Satoshi NittaHiroyuki Nishiyama

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