PMID: 3756789Oct 15, 1986Paper

Importance of critical metabolites and cellular interactions in the biology of microregions of tumors

Cancer
R M Sutherland

Abstract

Heterogeneity of cellular microenvironments and associated differences in phenotypic expression of cells in solid tumors occur as a consequence of deficiencies of vascularization. Intervascular microregions of tumors and micrometastases can be modeled by multicellular spheroids in vitro. These develop concentration gradients of critical metabolites such as oxygen, glucose, and probably also other important nutrients, hormones, and growth factors. Drug penetration may also be reduced. Concentrations of these factors decrease from the periphery towards the center, but gradients develop in the opposite direction for certain metabolic and necrotic products such as lactate and pH. Such gradients significantly modify the proliferative status of the cells, viability, clonogenicity, cell cycle distribution, antigen expression, and differentiation. Stress of oxygen and glucose deprivation induces synthesis of a specific set of proteins. Cellular interactions can also modulate phenotypic expression, including oxygen and glucose consumption rates and sensitivity to radiation and drugs. The mechanisms of these are unknown, but changes in cell-cell communication and DNA damage and repair have been demonstrated in spheroids. Microenvironment...Continue Reading

References

Mar 1, 1979·Microvascular Research·P VaupelW A Grunewald
Aug 1, 1979·International Journal of Radiation Oncology, Biology, Physics·R M SutherlandD Vanantwerp
Apr 1, 1986·International Journal of Radiation Oncology, Biology, Physics·R SutherlandB Sordat
Jul 1, 1986·International Journal of Radiation Oncology, Biology, Physics·L L LingR Sutherland
Aug 1, 1986·International Journal of Radiation Oncology, Biology, Physics·C S Heacock, R M Sutherland
Feb 1, 1985·Journal of Cellular Physiology·J C Wigle, R M Sutherland
Mar 1, 1986·British Journal of Cancer·W Mueller-KlieserR M Sutherland
Mar 1, 1972·Experimental Cell Research·R E Durand, R M Sutherland
Jan 1, 1984·Recent Results in Cancer Research. Fortschritte Der Krebsforschung. Progrès Dans Les Recherches Sur Le Cancer·H Dertinger, D F Hülser
Feb 1, 1982·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·R E Durand
Jan 1, 1984·Recent Results in Cancer Research. Fortschritte Der Krebsforschung. Progrès Dans Les Recherches Sur Le Cancer·R M Sutherland, R E Durand
Jan 1, 1984·Recent Results in Cancer Research. Fortschritte Der Krebsforschung. Progrès Dans Les Recherches Sur Le Cancer·T Nederman, P Twentyman
Aug 1, 1984·International Journal of Radiation Oncology, Biology, Physics·C J KochK A Baer
Aug 1, 1984·Proceedings of the National Academy of Sciences of the United States of America·J J SciandraC S Hughes
Jan 1, 1984·Journal of Cellular Physiology·J P FreyerR M Sutherland
Jan 15, 1984·International Journal of Cancer. Journal International Du Cancer·R LotanA Ben-Ze'ev
Feb 1, 1982·British Journal of Cancer·W F Mueller-Klieser, R M Sutherland
Mar 1, 1982·International Journal of Radiation Oncology, Biology, Physics·A J FrankoC J Koch
Jan 1, 1981·Radiation and Environmental Biophysics·H Dertinger, D Hülser
Oct 1, 1981·International Journal of Radiation Oncology, Biology, Physics·W Mueller-KlieserR Schmidseder

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Citations

May 29, 1996·International Journal of Cancer. Journal International Du Cancer·A KonurR Andreesen
Mar 20, 1998·International Journal of Cancer. Journal International Du Cancer·M WartenbergH Sauer
Sep 22, 2007·Bulletin of Mathematical Biology·K E Thompson, J A Royds
Aug 13, 2005·Journal of Cancer Research and Clinical Oncology·Fabian FehlauerPeter Sminia
Aug 30, 1995·International Journal of Radiation Oncology, Biology, Physics·N KubotaS Matsubara
Sep 11, 2013·Biomaterials·Ruslan I DmitrievDmitri B Papkovsky
Oct 18, 2000·Critical Reviews in Oncology/hematology·J M PadrónG J Peters
Oct 18, 2000·Critical Reviews in Oncology/hematology·B Desoize, J Jardillier
Jan 31, 1995·Proceedings of the National Academy of Sciences of the United States of America·D ShweikiE Keshet
Jul 1, 1994·International Journal of Hyperthermia : the Official Journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group·S L VadenJ E Riviere
Mar 12, 1991·International Journal of Cancer. Journal International Du Cancer·B Bourrat-FloeckW Mueller-Klieser
Oct 15, 1994·International Journal of Cancer. Journal International Du Cancer·K SakataR M Sutherland
Apr 1, 1989·International Journal of Radiation Oncology, Biology, Physics·E K RofstadR M Sutherland
Mar 1, 1994·International Journal of Radiation Oncology, Biology, Physics·J M ClineJ A Raleigh
Jan 10, 2012·Biotechnology Progress·Bhushan J ToleyNeil S Forbes
Jan 1, 1990·Critical Reviews in Oncology/hematology·C N Coleman, A T Turrisi
Nov 10, 2004·Cancer Letters·Maria Alves dos SantosRui Curi
Aug 1, 1989·European Journal of Cancer & Clinical Oncology·J Carlsson, T Nederman
Aug 1, 1988·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·E K RofstadR M Sutherland
Dec 23, 2014·Journal of Cellular Biochemistry·Angela M OttoCornelia Janzon
Feb 1, 2006·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Hiroyasu YasudaHidetada Sasaki
Sep 5, 2008·Current Protocols in Cytometry·S Chow, D Hedley

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