Importance of cytomegalovirus viraemia in risk of disease progression and death in HIV-infected patients receiving highly active antiretroviral therapy

Lancet
Jane R DeaytonPaul D Griffiths

Abstract

Before highly active antiretroviral therapy (HAART) became available, cytomegalovirus was a major cause of opportunistic infection in HIV-infected patients and was associated with accelerated progression to AIDS and death. We have investigated whether cytomegalovirus viraemia remains a significant risk factor for progression of HIV disease and death in the era of HAART. 374 patients whose CD4-cell count had ever been below 100 per microL were enrolled in a prospective study. Serial blood samples were tested for cytomegalovirus by PCR. Rates of new cytomegalovirus disease, new AIDS-defining disorders, and death were calculated over a median follow-up of 37 months after stratification according to baseline and most recent cytomegalovirus PCR status at any point during follow-up. Of 2969 PCR assays, 375 (12.6%) were positive for cytomegalovirus DNA. 259 (69.3%) patients were persistently negative for cytomegalovirus by PCR; 15 were persistently positive; and 100 were intermittently positive and negative. In multivariate models, cytomegalovirus PCR-positive status as a time-updated covariate was significantly associated with increased relative rates of progression to a new AIDS-defining disorder (2.22 [95% CI 1.27-3.88] p=0.005) an...Continue Reading

References

Jul 1, 1990·American Journal of Hematology·P R BechererG C White
Apr 1, 1994·The Journal of Infectious Diseases·R DetelsJ V Giorgi

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Citations

Jul 10, 2007·Current Infectious Disease Reports·Arthur Y Kim, Georg M Lauer
Jun 13, 2012·Current Infectious Disease Reports·Lisa Barrett, Sharon Walmsley
Jul 23, 2009·The Journal of Biological Chemistry·Egor P TchesnokovMatthias Götte
May 1, 2008·The Journal of Infectious Diseases·Mary K WlochMichael Boeckh
Mar 21, 2013·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Nicolas DurierAnchalee Avihingsanon
Apr 12, 2012·The Journal of Infectious Diseases·Christina M ParrinelloRobert C Kaplan
Jul 2, 2005·AIDS·Gillian C HarcourtUNKNOWN Hemophilia Growth and Development Study (HGDS)
May 30, 2009·The Pediatric Infectious Disease Journal·Shannon A RossSuresh B Boppana
Dec 15, 2010·The Pediatric Infectious Disease Journal·Marco ZampoliHeather J Zar
Jul 11, 2006·Proceedings. Biological Sciences·Roland R RegoesVincent C Emery
Jul 7, 2011·HIV Medicine·Ma JacobsonP Hunt
Jan 22, 2011·HIV Medicine·E Boffi El AmariUNKNOWN Swiss HIV Cohort Study
Oct 13, 2006·Journal of Virology·Martin R GoodierF Gotch
Sep 23, 2009·The Journal of Clinical Investigation·Ronald E Gress, Steven G Deeks
Nov 26, 2011·BMC Infectious Diseases·David Heiden, Peter Saranchuk
Sep 24, 2010·PloS One·Beda BrichacekLeonid Margolis
Aug 22, 2013·The Journal of Infectious Diseases·Sara GianellaDavey M Smith
Jan 1, 2014·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Adriana WeinbergMark A Jacobson
Apr 24, 2014·The Journal of Infectious Diseases·Peter W HuntMichael M Lederman
Jul 6, 2014·Current Opinion in Immunology·Heidi J Zapata, Albert C Shaw
Mar 29, 2005·Journal of Acquired Immune Deficiency Syndromes : JAIDS·David A WohlCharles van der Horst
Nov 8, 2008·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Laila DarwichMargarita Bofill
May 8, 2009·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Romain MicolMarianne Leruez-Ville
Jan 1, 2006·Current Opinion in HIV and AIDS·Margarita BofillLidia Ruiz
Mar 11, 2011·Enfermedades infecciosas y microbiología clínica·José Alcamí, Mayte Coiras
May 1, 2010·Medicina intensiva·A CortésE Bautista
Feb 23, 2010·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·E RidhaM Nelson
Jul 26, 2008·The Lancet Infectious Diseases·Philippe Van de PerreNicolas Nagot
Dec 7, 2007·Infectious Disease Clinics of North America·Arnaud HotOlivier Lortholary
Nov 1, 2015·The Journal of Infectious Diseases·Barbra A RichardsonJennifer A Slyker

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