Importance of detection of SS-A/Ro autoantibody in screening immunofluorescence tests for autoantibodies to nuclear antigens

Journal of Clinical Laboratory Analysis
D J Bylund, R M Nakamura

Abstract

SS-A/Ro autoantibodies are related to Sjögren's syndrome and to several clinical subsets of lupus erythematosus. The most widely used laboratory procedure for ANA screening is the indirect immunofluorescence test (IF-ANA); the laboratory detection of anti-SS-A/Ro requires implementation and adherence to several technical and quality assurance recommendations. Using appropriate substrate cells containing the SS-A/Ro antigen, many so-called "ANA-negative" lupus erythematosus patients will demonstrate a positive IF-ANA.

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Citations

Feb 28, 2002·American Journal of Clinical Pathology·Renato TozzoliItalian Society of Laboratory Medicine Study Group on the Diagnosis of Autoimmune Diseases
Jun 1, 1997·Critical Reviews in Clinical Laboratory Sciences·L M Hang, R M Nakamura

Related Concepts

Ro60 antigen
Y5 RNA, Ro ribonucleoprotein, human
Fluorescent Antinuclear Antibodies
Autoantigens
Immunofluorescence Assay
Lupus Erythematosus, Subacute Cutaneous
Lupus Erythematosus, Systemic
Ribonucleoproteins
Sicca Syndrome
RNA, Small Cytoplasmic

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