Importance of ERK1/2 in Regulation of Protein Translation during Oocyte Meiosis

International Journal of Molecular Sciences
Jaroslav KalousAndrej Susor

Abstract

Although the involvement of the extracellular signal-regulated kinases 1 and 2 (ERK1/2) pathway in the regulation of cytostatic factor (CSF) activity; as well as in microtubules organization during meiotic maturation of oocytes; has already been described in detail; rather less attention has been paid to the role of ERK1/2 in the regulation of mRNA translation. However; important data on the role of ERK1/2 in translation during oocyte meiosis have been documented. This review focuses on recent findings regarding the regulation of translation and the role of ERK1/2 in this process in the meiotic cycle of mammalian oocytes. The specific role of ERK1/2 in the regulation of mammalian target of rapamycin (mTOR); eukaryotic translation initiation factor 4E (eIF4E) and cytoplasmic polyadenylation element binding protein 1 (CPEB1) activity is addressed along with additional focus on the other key players involved in protein translation.

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Citations

Jul 11, 2019·Biology of Reproduction·Anna TetkovaJaroslav Kalous
Jan 31, 2020·Journal of Thrombosis and Haemostasis : JTH·Bhanu Kanth ManneMatthew T Rondina
Sep 8, 2019·Cellular and Molecular Life Sciences : CMLS·Jue ZhangHeng-Yu Fan
Oct 20, 2018·Nucleic Acids Research·Xing-Xing DaiHeng-Yu Fan
Jun 16, 2019·International Journal of Molecular Sciences·Monserrat Olea-FloresNapoleón Navarro-Tito
Dec 8, 2020·Frontiers in Cell and Developmental Biology·Lan-Rui CaoHeng-Yu Fan
Mar 7, 2021·Animals : an Open Access Journal From MDPI·Seok Hee LeeIslam M Saadeldin
Aug 28, 2021·International Journal of Molecular Sciences·Martin AngerMarketa Charousova
Oct 1, 2021·Human Reproduction·Li LiGuoqing Tong

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