Importance of human papillomavirus (HPV) screening in the follow-up after CIN2-3 treatment

Journal de gynécologie, obstétrique et biologie de la reproduction
D RiethmullerR Maillet

Abstract

Cervical intraepithelial neoplasia (CIN) 2 and CIN3 lesions clearly represent precancerous states even if some of them would heal spontaneously. Management is based on surgical excision of part of the uterine cervix because such lesions can potentially progress into carcinomas. In most cases, this treatment leads to the cure of intraepithelial lesions. However, even after such an efficient treatment, theses patients are still at a higher risk of developing an invasive cervical cancer. That is why guidelines recommend a specific follow-up in order to screen for residual disease (incomplete excision) or for recurrences (after a complete excision). The actual problem in the follow-up strategy lies in the screening tools in use - cervical smears and colposcopy - whose sensitivities are low and hence, not quite sufficient when applied to a high risk population. These intraepithelial lesions are due to high risk human papillomaviruses (HPV) and there cannot be any lesion progression without HPV. Consequently, a viral testing would help in identifying a high risk subpopulation of women after cone loop cervical excision. We studied, retrospectively, the contribution of HPV testing (Hybrid Capture 2((R))) in the follow-up after CIN2-3 t...Continue Reading

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Citations

Dec 17, 2009·Archives of Gynecology and Obstetrics·Raffaella RibaldoneNicola Surico
Apr 5, 2016·European Journal of Obstetrics, Gynecology, and Reproductive Biology·Susan M ShermanCharles W E Redman
Apr 2, 2013·The Cochrane Database of Systematic Reviews·Marc ArbynWalter J Prendiville
Sep 15, 2019·Gynécologie, Obstétrique, Fertilité & Sénologie·C GonthierG Canlorbe

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