PMID: 9421737Jan 9, 1998Paper

Importance of interferon-gamma in protective immunity against Hymenolepis nana cysticercoids derived from challenge infection with eggs in BALB/c mice

International Journal for Parasitology
K Asano, K Muramatsu

Abstract

The function of cytokines produced during Hymenolepis nana egg infection in mice in protective immunity against re-infection was examined. Treatment of mice with monoclonal antibody (MAb) against mouse interferon (IFN)-gamma caused suppression of protective immunity against H. nana re-infection when the MAb was injected intraperitoneally at a daily dose of 40.0 mg kg-1 during the effector phase of protective immunity. Although high levels of IFN-gamma, tumor necrosis factor (TNF)-alpha and interleukin (IL)-1 beta were released into the intestinal tracts of the parasitised mice at challenge infection, there was almost no release of these cytokines in mice treated with the MAb. Daily administration of rolipram failed to suppress the protective immunity, even when 400 micrograms kg-1 of the agent was administered into mice during the effector phase of immunity. Treatment of mice with rolipram completely suppressed both TNF-alpha and IL-1 beta production in intestinal tracts, induced by H. nana challenge infection. However, endogenous IFN-gamma production in the intestine was scarcely affected by rolipram. These results strongly suggest that IFN-gamma is the most important (or essential) cytokine in protective immunity to H. nana r...Continue Reading

References

Dec 1, 1992·Immunology and Cell Biology·K AsanoK Okamoto
Apr 1, 1985·The Journal of Clinical Investigation·J W KazuraM Aikawa
Feb 1, 1987·The Journal of Clinical Investigation·C F Nathan
Dec 1, 1986·Experimental Parasitology·R ChandrashekarD Subrahmanyam
Dec 1, 1982·The Journal of Experimental Medicine·P S SteegJ J Oppenheim
Feb 1, 1993·International Journal for Parasitology·K AsanoK Okamoto

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Citations

Jan 10, 2009·Evidence-based Complementary and Alternative Medicine : ECAM·Takako MatsudaTadashi Hisamitsu

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