PMID: 2123170Jan 1, 1990Paper

Importance of mast-cell-derived eosinophil chemotactic factor A on granuloma formation in murine Schistosomiasis japonica: evaluation using mast-cell-deficient W/WV mice

International Archives of Allergy and Applied Immunology
M OwhashiY Nawa

Abstract

The role of mast-cell-derived eosinophil chemotactic factor A (ECF-A) on eosinophil-rich periovular granuloma formation was examined by using mast-cell-deficient WBB6F1-W/WV mice infected with Schistosoma japonicum. The average size of granulomas formed around newly deposited eggs in the liver of W/WV mice was significantly smaller than that observed in control +/+ mice. The number of adult worms recovered or specific IgE titers were comparable between W/WV and +/+ mice. In contrast, immediate-type hypersensitivity response to specific antigen and dialyzable low-molecular weight ECF in the serum was detectable only in infected +/+ mice. When naive bone marrow eosinophils were incubated with the dialyzable fraction of infected +/+ mice sera, chemotactic reactivity of eosinophils to ECF derived from S. japonicum eggs was significantly enhanced, although that to synthetic ECF-A was depressed. Similar effects were observed when naive eosinophils were treated with synthetic ECF-A. The dialyzable fraction of infected W/WV mice sera had no such modulating effect on the chemotactic reactivity of eosinophils. These results suggest that an immediate-type hypersensitivity reaction is important in the formation of eosinophilic granulomas a...Continue Reading

Citations

May 27, 2016·Seminars in Immunopathology·Kaori MukaiStephen J Galli
Mar 5, 2004·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Thomas A WynnMargaret M Mentink-Kane

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