PMID: 22554276May 5, 2012Paper

Importance of metabolic activation study to the safe use of Chinese herbal medicines

Current Drug Metabolism
Bin MaGe Lin

Abstract

The number of new drugs approved for clinical use per year is falling in the last decade. One approach to reduce the high rate of attrition during early drug development is to systematically determine the toxic metabolites on the mechanism basis. Traditional Chinese herbal medicines (CHM) have been used extensively for disease treatment and health care. Recently, they have also been used as raw materials for preparation of herbal dietary supplements and nutraceuticals worldwide. However, problems arise due to the adverse effects caused by CHM and their derived products. Similar to synthetic drugs, among the diverse mechanisms the metabolism-induced adverse effect/toxicity is an important safety issue of CHM. For safe use of CHM and herbal products, it is also necessary to study herbinduced toxicities using the mechanism-based approach. CHM consist of multi-ingredients, which makes the study of toxic metabolites more difficult and challenging than that of synthetic drug-induced toxicity. In this mini-review, using hepatotoxicity and nephrotoxicity induced respectively by metabolic activation of pyrrolizidine alkaloids and aristolochic acid present in CHM as examples, we address the significance of metabolic study of CHM and how ...Continue Reading

Citations

Sep 24, 2015·Journal of Environmental Science and Health. Part C, Environmental Carcinogenesis & Ecotoxicology Reviews·Jianqing RuanGe Lin
May 17, 2017·Journal of Environmental Science and Health. Part C, Environmental Carcinogenesis & Ecotoxicology Reviews·Na LiGe Lin
May 20, 2014·Chemical Research in Toxicology·Jianqing RuanGe Lin

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