Importance of metabolic function of the natural lung evaluated by prolonged exclusion of the pulmonary circulation

ASAIO Journal : a Peer-reviewed Journal of the American Society for Artificial Internal Organs
K EyaH Takano

Abstract

It is generally considered that the natural lung metabolizes various vasoactive substances through the pulmonary circulation. However, the influences of bypassing or eliminating the pulmonary circulation have not been fully elucidated, especially for prolonged periods. In this study, we performed total cardiopulmonary bypass and exclusion of the pulmonary circulation for up to 336 hr in awake goats to clarify the importance of the metabolic function of the lung. In seven adult goats, biventricular bypass with a pulsatile ventricular assist system was first established. After 2 weeks, the biventricular bypass was converted to total cardiopulmonary bypass without anesthesia. Adequate gas exchange and perfusion support were achieved in all animals. However, the institution of total cardiopulmonary bypass led to marked decreases in the mean aortic pressure and systemic vascular resistance, and they remained low thereafter. The arterial levels of prostaglandin E2 and norepinephrine, which are inactivated naturally through the pulmonary circulation, increased remarkably. These results indicate that the natural lung plays an important role in controlling systemic circulation by metabolizing various vasoactive substances. Understanding...Continue Reading

Citations

May 15, 2012·ASAIO Journal : a Peer-reviewed Journal of the American Society for Artificial Internal Organs·Begum AkayKeith E Cook
Sep 25, 2007·The Annals of Thoracic Surgery·Hitoshi SatoKeith E Cook
Jul 9, 2010·The Annals of Thoracic Surgery·Begum AkayKeith E Cook
Feb 10, 2000·ASAIO Journal : a Peer-reviewed Journal of the American Society for Artificial Internal Organs·F BoschettiL F Mockros
Oct 23, 2004·ASAIO Journal : a Peer-reviewed Journal of the American Society for Artificial Internal Organs·Michel KindoO H Frazier
Sep 15, 2005·ASAIO Journal : a Peer-reviewed Journal of the American Society for Artificial Internal Organs·Carrie E PerlmanLyle F Mockros

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