Importance of methyl donors during reproduction.

The American Journal of Clinical Nutrition
Steven H Zeisel

Abstract

Evidence is growing that optimal dietary intake of folate and choline (both involved in one-carbon transfer or methylation) is important for successful completion of fetal development. Significant portions of the population are eating diets low in one or both of these nutrients. Folates are important for normal neural tube closure in early gestation, and the efficacy of diet fortification with folic acid in reducing the incidence of neural tube defects is a major success story for public health nutrition. Similarly, maternal dietary choline is important for normal neural tube closure in the fetus and, later in gestation, for neurogenesis in the fetal hippocampus, with effects on memory that persist in adult offspring; higher choline intake is associated with enhanced memory performance. Although both folates and choline have many potentially independent mechanisms whereby they could influence fetal development, these 2 nutrients also have a common mechanism for action: altered methylation and related epigenetic effects on gene expression.

References

Dec 1, 1976·Archives of Disease in Childhood·R W SmithellsC J Schorah
Nov 5, 1991·Biochimica Et Biophysica Acta·K HanadaY Akamatsu
Jan 1, 1990·Progress in Lipid Research·C Kent
May 1, 1988·Developmental Psychobiology·W H MeckC L Williams
Jan 1, 1986·Acta Obstetricia Et Gynecologica Scandinavica·I QvistS Svensson
Jun 30, 1985·Clinica Chimica Acta; International Journal of Clinical Chemistry·K E McMahon, P M Farrell
Nov 9, 1968·British Medical Journal·M L Willoughby, F G Jewell
Aug 1, 1980·Metabolism: Clinical and Experimental·S H MuddC R Scriver
Aug 12, 1983·Science·J K Blusztajn, R J Wurtman
Jan 1, 1993·Mutation Research·R Holliday, G W Grigg
Oct 1, 1996·The American Journal of Clinical Nutrition·M Q Holmes-McNaryS H Zeisel
Mar 18, 1997·Proceedings of the National Academy of Sciences of the United States of America·P A Jones, M L Gonzalgo
Aug 1, 1997·Trends in Genetics : TIG·R Jaenisch
Nov 25, 1997·Biochimica Et Biophysica Acta·D E VanceZ Cui
Mar 5, 1999·Brain Research. Developmental Brain Research·C D AlbrightS H Zeisel
Dec 28, 1999·Brain Research. Developmental Brain Research·W H Meck, C L Williams
Sep 30, 2000·Seminars in Thrombosis and Hemostasis·J D Finkelstein
Mar 10, 2001·The American Journal of Clinical Nutrition·P F JacquesJ Selhub
Mar 27, 2001·Nature Reviews. Genetics·K D Robertson, A P Wolffe
Mar 29, 2002·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Melanie C FisherThomas W Sadler
Apr 5, 2002·Chembiochem : a European Journal of Chemical Biology·Albert Jeltsch
Aug 7, 2002·The Journal of Nutrition·Mihai D Niculescu, Steven H Zeisel
Aug 7, 2002·The Journal of Nutrition·Craig A CooneyGeorge L Wolff
May 6, 2003·The Journal of Nutrition·Gery R SteengeMartijn B Katan
May 6, 2003·The Journal of Nutrition·Steven H ZeiselJoanne M Holden

❮ Previous
Next ❯

Citations

Oct 13, 2011·JAMA : the Journal of the American Medical Association·Christine RothEzra Susser
Apr 27, 2011·Journal of Autism and Developmental Disorders·Stepan MelnykS Jill James
Sep 22, 2011·Neuroscience Bulletin·Elisabetta Biasi
Nov 30, 2011·The Proceedings of the Nutrition Society·Paula Dominguez-SalasSophie E Moore
Sep 17, 2010·Current Opinion in Pediatrics·Kersti K Linask, James Huhta
Jul 16, 2010·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Margaret J R HeerwagenJacob E Friedman
Apr 24, 2012·Journal of Toxicology·Megan N Hall, Mary V Gamble
Jul 5, 2012·Current Gerontology and Geriatrics Research·Fabio CoppedèAron M Troen
Dec 3, 2011·The American Journal of Clinical Nutrition·Anna E BeaudinPatrick J Stover
Dec 17, 2008·The American Journal of Clinical Nutrition·Mary Frances Picciano, Michelle K McGuire
Jan 1, 2009·The American Journal of Clinical Nutrition·Susan E Carlson
Jan 1, 2009·The American Journal of Clinical Nutrition·Steven H Zeisel
May 28, 2010·The American Journal of Clinical Nutrition·J Richard PilsnerMauricio Hernández-Avila
Jun 11, 2010·The American Journal of Clinical Nutrition·Regan L BaileyMary Frances Picciano
Oct 25, 2012·Journal of Oncology·Rita RosatiDiane C Cabelof
Nov 12, 2014·Applied Physiology, Nutrition, and Metabolism = Physiologie Appliquée, Nutrition Et Métabolisme·Faiqa FayyazUNKNOWN APrON Study Team
Feb 22, 2013·American Journal of Epidemiology·Caroline E BoekeEmily Oken
May 7, 2010·Journal of Inherited Metabolic Disease·Per Magne Ueland
Jul 6, 2010·Journal of Bone and Mineral Metabolism·Arash Hossein-nezhadBagher Larijani
Sep 11, 2012·Toxicology and Applied Pharmacology·Verne TsangZuzana Drobná
Jun 18, 2015·European Journal of Clinical Nutrition·H T CuetoE M Mikkelsen
Jul 5, 2011·Pediatric Neurology·Işıl ÖzerŞemsettin Şahin
May 14, 2010·Metabolism: Clinical and Experimental·Melissa SuterKjersti Aagaard-Tillery
Mar 12, 2010·Mechanisms of Ageing and Development·Michael Fenech
Oct 27, 2015·Journal of Agricultural and Food Chemistry·Filip KiekensChristophe P Stove
Oct 1, 2010·Maternal & Child Nutrition·Katalin FeketeTamás Decsi
Jun 14, 2012·Birth Defects Research. Part C, Embryo Today : Reviews·Irene E Zohn
Oct 9, 2012·Journal of Child Psychology and Psychiatry, and Allied Disciplines·Catherine MonkErin A Osterholm

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.