Importance of outer-sphere and aggregation phenomena in the relaxation properties of phosphonated gadolinium complexes with potential applications as MRI contrast agents

Chemistry : a European Journal
Mourad ElhabiriLoïc J Charbonnière

Abstract

A series composed of a tetra-, a tris- and a bisphosphonated ligand based on a pyridine scaffold (L(4) , L(3) and L(2) , respectively) was studied within the frame of lanthanide (Ln) coordination. The stability constants of the complexes formed with lanthanide cations (Ln=La, Nd, Eu, Gd, Tb, Er and Lu) were determined by potentiometry in aqueous solutions (25.0 °C, 0.1 M NaClO4 ), showing that the tetraphosphonated complexes are among the most stable Ln(III) complexes reported in the literature. The complexation of L(4) was further studied by different titration experiments using mass spectrometry and various spectroscopic techniques including UV/Vis absorption, and steady state and time-resolved luminescence (Ln=Eu and Tb). Titration experiments confirmed the formation of highly stable [LnL(4) ] complexes. (31) P NMR experiments of the LuL(4) complex revealed an intramolecular interconversion process which was studied at different temperatures and was rationalized by DFT modelling. The relaxivity properties of the Gd(III) complexes were studied by recording their (1) H NMRD profiles at various temperatures, by temperature dependent (17) O NMR experiments (GdL(4) ) and by pH dependent relaxivity measurements at 0.47 T (GdL(3) a...Continue Reading

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Citations

Feb 26, 2016·Chemical Communications : Chem Comm·Mohamadou SyLoïc J Charbonnière
Mar 30, 2016·Dalton Transactions : an International Journal of Inorganic Chemistry·Xiaomin Hou, Si-Fu Tang
Jun 14, 2018·Angewandte Chemie·Peter HarveyLoïc J Charbonnière
Jan 11, 2020·Chemistry : a European Journal·Loic Joanny CharbonnièreMauro Botta
Sep 30, 2017·Physical Chemistry Chemical Physics : PCCP·Jan BlahutCarlos Platas-Iglesias
Jan 8, 2019·Journal of the American Chemical Society·Aline NonatLoïc J Charbonnière
Dec 19, 2016·Inorganic Chemistry·Nabila SouriLoïc J Charbonnière
Nov 24, 2021·Angewandte Chemie·Huan WangEric M Gale

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