PMID: 9165136Apr 1, 1997Paper

Importance of overall treatment time for the outcome of radiotherapy of advanced head and neck carcinoma: dependency on tumor differentiation

Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology
Olfred HansenA Berthelsen

Abstract

Accelerated repopulation of tumor cells during radiotherapy has been suggested as an important cause of treatment failure in squamous cell carcinoma of the head and neck. Due to tumor heterogeneity, not all tumors may benefit from accelerated radiotherapy at the expense of a lower total dose. This analysis evaluates the impact of histological differentiation on loco-regional control in relation to treatment duration. A total of 501 patients with advanced supraglottic and pharyngeal squamous cell carcinoma with known histopathological grading were treated with planned split-course (191 patients) or continuous radiotherapy (310 patients) in two consecutive randomized controlled trials. Irradiation was given 2 Gy per fraction, 5 fractions per week to a dose of 66-68 Gy in 9.5 or 6.5 weeks, respectively. Overall, split-course and continuous treatment resulted in a 5-year loco-regional control of 30% and 41% (P = 0.007), respectively. However, the detrimental effects of split-course were only found in moderately and well-differentiated tumors, where the 5-year tumor controls were 38% and 21% after continuous and split-course treatment, respectively (P = 0.001). In contrast, in poorly differentiated tumors loco-regional control was o...Continue Reading

References

Jan 1, 1992·International Journal of Radiation Oncology, Biology, Physics·C A LochrinM I Saunders
Oct 1, 1991·International Journal of Radiation Oncology, Biology, Physics·C H TerhaardG J Hordijk
Jan 1, 1991·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·J OvergaardA Berthelsen
Mar 1, 1990·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·W Dörr, J Kummermehr
May 1, 1989·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·S DischeN J McNally
Jan 1, 1988·Acta Oncologica·H R WithersB Maciejewski
Jan 1, 1988·Acta Oncologica·M I SaundersC Des Rochers
Apr 1, 1986·International Journal of Radiation Oncology, Biology, Physics·J OvergaardM Hjelm Hansen
May 1, 1995·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·W Van den BogaertM van Glabbeke
Aug 1, 1993·International Journal of Radiation Oncology, Biology, Physics·M S RudoltzM Mohiuddin
Aug 1, 1993·International Journal of Radiation Oncology, Biology, Physics·J BourhisE P Malaise
Sep 1, 1995·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·W Van den BogaertE van der Schueren
Sep 1, 1995·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·G D WilsonM I Saunders
Jun 1, 1996·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·J CarlO Greisen
Sep 1, 1996·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·R G BristowR P Hill
Sep 1, 1996·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Y NishimuraH Kojima
Feb 1, 1996·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·S M BentzenH D Thames

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Citations

Mar 9, 2004·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·Jürg KutterRoger Stupp
Dec 10, 2009·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·Sabrina FalkowskiPierre Clavère
Dec 21, 2000·Current Oncology Reports·K S Hu, L B Harrison
Mar 6, 2013·Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico·P PediciniG Storto
Jan 31, 2004·International Journal of Radiation Oncology, Biology, Physics·F HesselM Baumann
Apr 9, 2005·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Jesper G EriksenUNKNOWN Danish Head and Neck Cancer study group (DAHANCA)
Jun 28, 2000·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·J Van de SteeneG Storme
Apr 28, 2001·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·M BaumannD Zips
Apr 28, 2001·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·J AlsnerJ Overgaard
May 23, 2001·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·A BoströmJ Bergh
Jul 6, 2001·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·V P MurielJ de Dios Luna del Castillo
Sep 16, 2003·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Raghavendra V GowdaNicholas J Slevin
Aug 1, 1997·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·S DischeM Parmar
May 4, 1999·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·M BaumannH Baisch
Jan 7, 2000·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·J P WylieN J Slevin
Feb 15, 2001·International Journal of Radiation Oncology, Biology, Physics·J AlsnerJ Overgaard
Feb 15, 2001·International Journal of Radiation Oncology, Biology, Physics·K Haustermans, J F Fowler
Jul 4, 1998·International Journal of Radiation Oncology, Biology, Physics·A RovirosaA Biete
Mar 4, 2000·International Journal of Radiation Oncology, Biology, Physics·R MohanR Schmidt-Ullrich
Oct 3, 1999·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·E Sham, R E Durand
Jul 27, 2001·Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society·J R KouvarisL J Vlahos
Aug 2, 2002·The Laryngoscope·Christian GodballeLars Bastholt
Mar 12, 2011·Anti-cancer Drugs·Cécile OrtholanYazid Belkacemi
Mar 22, 2002·The Lancet Oncology·A J Davis, J F Tannock
Feb 19, 2016·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·Tomoya YokotaSadamoto Zenda
Feb 24, 2016·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Annika LattermannMechthild Krause
Dec 26, 2015·Bulletin du cancer·Jean-Baptiste GuyNicolas Magné
May 4, 2010·International Journal of Radiation Oncology, Biology, Physics·Chien-Yu LinJoseph Tung-Chieh Chang
Jun 23, 2009·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Jens Overgaard
Aug 19, 2008·International Journal of Radiation Oncology, Biology, Physics·Shao Hui HuangBrian O'Sullivan
Apr 2, 2013·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Rebecca Bütof, Michael Baumann
Aug 11, 2015·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Nina M LyhneJens Overgaard
Sep 29, 2004·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Jesper G EriksenJens Overgaard
Jun 9, 2004·International Journal of Radiation Oncology, Biology, Physics·Té VuongCarolyn Freeman
Nov 10, 2015·Reports of Practical Oncology and Radiotherapy : Journal of Greatpoland Cancer Center in Poznań and Polish Society of Radiation Oncology·José A González FerreiraBranislav Jeremic
Jun 30, 2015·Cancer radiothérapie : journal de la Société française de radiothérapie oncologique·J BiauM Lapeyre

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