Importance of oxidative stress in the pathogenesis and treatment of asthma

Current Opinion in Allergy and Clinical Immunology
Marc A Riedl, Andre E Nel

Abstract

The purpose of the current review is to summarize recent evidence demonstrating the important role of oxidative stress in asthma pathogenesis. The therapeutic implications of these findings will be presented. Mechanistically, the effect of oxidative stress on dendritic cells has been demonstrated to have a potent effect on Th1/Th2 skewing of the immune response. Investigations of gene-environment interactions have identified genetic polymorphisms associated with individual susceptibility to pollutant-induced respiratory oxidative stress. The effects of current asthma therapy on oxidative stress are currently unclear, but previous trials using conventional antioxidant therapy in asthma have been largely ineffective. Recent investigations have identified two promising broad-based therapeutic approaches: Nrf2 pathway activation and the use of thiol precursors. Preliminary data suggest that fullerene nanomaterials and dietary interventions may also have potential benefits in asthma. Our current understanding of the role of oxidative stress in asthma suggests that antioxidant therapy may be important in optimizing asthma treatment and prevention. The future success of antioxidant asthma therapy will require strategies with broad eff...Continue Reading

References

Apr 18, 1998·Proceedings of the National Academy of Sciences of the United States of America·J D PetersonC Waltenbaugh
Sep 9, 1998·American Journal of Respiratory Cell and Molecular Biology·S FujiedaA Saxon
Mar 17, 1999·Clinical Immunology : the Official Journal of the Clinical Immunology Society·D Diaz-SanchezA Saxon
Nov 24, 1999·Inhalation Toxicology·P A SteerenbergH van Loveren
Dec 10, 1999·The Journal of Allergy and Clinical Immunology·D Diaz-SanchezA Saxon
May 12, 2000·American Journal of Respiratory and Critical Care Medicine·A A FryerM A Spiteri
Aug 10, 2000·American Journal of Respiratory and Critical Care Medicine·T Kobayashi
Jan 10, 2001·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·S A ComhairS C Erzurum
Sep 21, 2001·British Journal of Pharmacology·R B MuijsersF P Nijkamp
Feb 23, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Michael J WhitekusAndre E Nel
Feb 28, 2002·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·T E IvaschenkoV S Baranov
Sep 5, 2002·The Journal of Allergy and Clinical Immunology·Russell P Bowler, James D Crapo
Mar 29, 2003·The European Respiratory Journal·S BlesaE J Morcillo
Jul 9, 2003·Cardiovascular Drug Reviews·Lawrence D Horwitz
Oct 2, 2003·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·A FogartyJ Britton
Dec 31, 2003·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Ning LiAndre E Nel
Aug 31, 2004·American Journal of Respiratory Cell and Molecular Biology·John A MarwickIrfan Rahman
Dec 23, 2004·Respirology : Official Journal of the Asian Pacific Society of Respirology·Lülüfer TamerUgur Atik
Feb 8, 2005·The Journal of Allergy and Clinical Immunology·Marc Riedl, David Diaz-Sanchez
Jul 7, 2005·The Journal of Experimental Medicine·Tirumalai RangasamyShyam Biswal
Sep 2, 2005·The European Respiratory Journal·V GarciaS O Shaheen
Dec 13, 2005·Respiratory Medicine·Andrew FogartyJohn Britton
Feb 4, 2006·Science·Andre NelNing Li
Feb 17, 2006·European Journal of Clinical Nutrition·H M Ochs-BalcomH J Schünemann
Mar 4, 2006·Public Health Nutrition·Walter C Willett
May 24, 2006·Free Radical Biology & Medicine·Jieru WangRobert J Mason
Jun 10, 2006·The American Journal of Clinical Nutrition·Sari VoutilainenTiina H Rissanen
Jun 30, 2006·Biochemical Pharmacology·Ana M WielandtJose Chianale
Jul 28, 2006·The European Respiratory Journal·I RomieuS London
Aug 8, 2006·The Journal of Allergy and Clinical Immunology·Ray Chun-Fai ChanAndre E Nel
Aug 15, 2006·American Journal of Physiology. Lung Cellular and Molecular Physiology·Stacey A RitzDavid Diaz-Sanchez
Aug 22, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Junxiang Wan, David Diaz-Sanchez
Oct 7, 2006·American Journal of Respiratory and Critical Care Medicine·Frank D GillilandDavid Diaz-Sanchez
Dec 13, 2006·American Journal of Respiratory Cell and Molecular Biology·Sandra M Wells, Andrij Holian
Feb 20, 2007·Toxicology and Applied Pharmacology·Rizwanul HaqueJoanna Floros
Mar 7, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·Niki L ReynaertYvonne M W Janssen-Heininger
Apr 26, 2007·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·M Martinez-LosaE J Morcillo
May 1, 2007·The Proceedings of the Nutrition Society·Ian T Johnson
May 4, 2007·Chest·Jane S BurnsFrank E Speizer
Jun 2, 2007·Respirology : Official Journal of the Asian Pacific Society of Respirology·Mohammed A Alzoghaibi, Ahmed S Bahammam

❮ Previous
Next ❯

Citations

Jan 22, 2010·Lung·Pierangelo GeppettiSerena Materazzi
Jul 28, 2012·Journal of Clinical Immunology·Taehoon LeeYou Sook Cho
Sep 4, 2012·Current Allergy and Asthma Reports·Saad SyedMarianne Frieri
Oct 1, 2009·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·Chan-Sun ParkHee-Bom Moon
Nov 26, 2011·The Proceedings of the Nutrition Society·Augusto A Litonjua
Jun 28, 2011·The Journal of Biological Chemistry·Prabakaran RavichandranGovindarajan T Ramesh
Sep 9, 2008·Antioxidants & Redox Signaling·John J MieyalMelissa D Shelton
Oct 20, 2011·Journal of Aerosol Medicine and Pulmonary Drug Delivery·Shama AhmadBarbara M Rothen-Rutishauser
May 12, 2011·Nicotine & Tobacco Research : Official Journal of the Society for Research on Nicotine and Tobacco·Karen M WilsonJonathan D Klein
Jun 2, 2012·TheScientificWorldJournal·Lyudmil TerzievGalya Stavreva
Apr 24, 2010·American Journal of Respiratory and Critical Care Medicine·So Ri KimYong Chul Lee
Jul 30, 2011·American Journal of Respiratory and Critical Care Medicine·Charalambos MichaeloudesKian Fan Chung
Mar 20, 2010·Respiratory Research·Norihiro KikuchiNobuyuki Hizawa
May 2, 2013·Journal of Inflammation·Adriana Sumoza-ToledoReinhold Penner
Nov 26, 2008·Journal of Neuroinflammation·Harumi JyonouchiHuma Quraishi
Nov 29, 2012·Annals of Thoracic Medicine·Asrar AhmadQayyum Husain
Apr 16, 2013·Pharmacology & Therapeutics·Ana L AlessandriMauro M Teixeira
Nov 12, 2014·The Journal of Asthma : Official Journal of the Association for the Care of Asthma·Marta NavratilMirjana Turkalj
Aug 17, 2014·International Journal of Cardiology·Wan-Leong ChanHsin-Bang Leu
Feb 2, 2012·Pulmonary Pharmacology & Therapeutics·Jian XuTing Xu
Dec 20, 2011·Free Radical Biology & Medicine·Kitti PazmandiAttila Bacsi
Oct 26, 2011·Molecular Aspects of Medicine·Robert L Norton, Peter R Hoffmann
Oct 8, 2011·Immunology and Allergy Clinics of North America·Zana L LummusDavid I Bernstein
Feb 22, 2011·Allergologia et immunopathologia·Ozlem GunayHasan Yuksel
Jan 29, 2011·The Journal of Allergy and Clinical Immunology·Si-Yen LiuChi-Chang Shieh
Aug 27, 2009·Toxicology in Vitro : an International Journal Published in Association with BIBRA·William E WixtedYolanda S López-Boado
Jun 30, 2009·The Journal of Allergy and Clinical Immunology·Emily J SwindleDonna E Davies
Nov 26, 2008·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Marc A RiedlDavid Diaz-Sanchez
Sep 9, 2008·The Journal of Allergy and Clinical Immunology·Jonathan CiencewickiSteven R Kleeberger
Jun 24, 2008·Immunology and Allergy Clinics of North America·Augusto A Litonjua
Jun 30, 2015·Free Radical Biology & Medicine·Miri AssayagNeville Berkman

❮ Previous
Next ❯

Related Concepts

Related Feeds

Asthma

This feed focuses in Asthma in which your airways narrow and swell. This can make breathing difficult and trigger coughing, wheezing and shortness of breath.

Allergy and Asthma

Allergy and asthma are inflammatory disorders that are triggered by the activation of an allergen-specific regulatory t cell. These t cells become activated when allergens are recognized by allergen-presenting cells. Here is the latest research on allergy and asthma.

Related Papers

Proceedings of the National Academy of Sciences of the United States of America
J D PetersonC Waltenbaugh
The Journal of Allergy and Clinical Immunology
Anne M FitzpatrickSevere Asthma Research Program
Proceedings of the American Thoracic Society
Yvonne M W Janssen-HeiningerAlbert van der Vliet
© 2021 Meta ULC. All rights reserved