Importance of physical fitness on predictive effect of body mass index and weight gain on incident atrial fibrillation in healthy middle-age men

The American Journal of Cardiology
Irene GrundvoldJohan Bodegard

Abstract

The incidence of both atrial fibrillation (AF) and obesity is increasing in the community, and lifestyle intervention is recommended. We aimed to test whether the predictive effect of body mass index (BMI) and weight change from age 25 years to midlife on incident AF were influenced by physical fitness. In 1972 to 1975, 2,014 healthy middle-age men conducted a bicycle exercise electrocardiographic test as a part of a cardiovascular survey program, defining physical fitness as work performed divided by body weight. During 35 years of follow-up, 270 men developed AF, documented by scrutiny of the health files in all Norwegian hospitals. Risk estimation was analyzed using Cox proportional hazard models and tested for age-adjusted physical fitness above and below the median. The mean BMI of 24.6 kg/m(2) defined a lean baseline cohort. The men with a baseline BMI of ≥28 kg/m(2) (11%) compared to a BMI <28 kg/m(2) had a 1.68-fold risk of AF (95% confidence interval 1.14 to 2.40) and men reporting weight gain of ≥10 kg (24%) compared to weight loss (11%) of 1.66-fold (95% confidence interval 1.00 to 2.89), respectively. The dichotomy into men with age-adjusted physical fitness above and below the median, demonstrated statistically sig...Continue Reading

References

Feb 25, 1993·The New England Journal of Medicine·L SandvikK Rodahl
Sep 16, 1998·Lancet·G ErikssenJ Erikssen
Nov 25, 2004·JAMA : the Journal of the American Medical Association·Thomas J WangEmelia J Benjamin
Aug 19, 2007·Thrombosis Research·Arnljot TveitHarald Arnesen
May 26, 2009·The American Journal of Cardiology·Anthony AizerChristine M Albert
Jul 28, 2009·Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology·Jawdat Abdulla, Jens Rokkedal Nielsen
Aug 12, 2009·International Journal of Obesity : Journal of the International Association for the Study of Obesity·X ZhangY Wu
Sep 12, 2009·Obesity Reviews : an Official Journal of the International Association for the Study of Obesity·M Fogelholm
Feb 2, 2010·Mayo Clinic Proceedings·Paul A McAuleyJonathan N Myers

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Citations

May 24, 2013·Netherlands Heart Journal : Monthly Journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation·M AlingsI C Van Gelder
Jan 31, 2016·Progress in Cardiovascular Diseases·Carl J LavieRichard V Milani
Feb 28, 2016·American Heart Journal·Anat BerkovitchElad Maor
Jun 22, 2013·Clinical Cardiology·Marijana TadicCesare Cuspidi
Jul 18, 2015·Progress in Cardiovascular Diseases·Arthur R MenezesFreddy M Abi-Samra
Apr 14, 2016·Mayo Clinic Proceedings·Charles FaselisHans Moore
Dec 30, 2014·Clinical Research in Cardiology : Official Journal of the German Cardiac Society·S Wernhart, M Halle
Oct 1, 2014·Progress in Cardiovascular Diseases·Laura F DeFinaKenneth H Cooper
Jun 9, 2016·Expert Review of Cardiovascular Therapy·Laurence LaplantePaul Khairy
Feb 15, 2018·Journal of Cardiovascular Electrophysiology·Zain AsadStavros Stavrakis
Jun 26, 2018·European Journal of Preventive Cardiology·Lars E GarnvikBjarne M Nes
Jun 24, 2017·American Journal of Epidemiology·Casey CrumpKristina Sundquist
Aug 22, 2014·Journal of the American Heart Association·Farnaz AzarbalMarco V Perez
Jun 8, 2014·Circulation. Arrhythmia and Electrophysiology·Rachel R HuxleyAlvaro Alonso
Dec 8, 2016·Circulation. Arrhythmia and Electrophysiology·Christopher X WongRobert Clarke
Aug 8, 2019·Current Sports Medicine Reports·Carl J LavieAndrew Elagizi
Mar 26, 2013·Orvosi hetilap·Péter Apor
Jan 15, 2021·BMJ Evidence-based Medicine·Kathryn S TaylorJeffrey K Aronson
Dec 19, 2020·Journal of Arrhythmia·Cecilia JohanssonLars Johansson

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