PMID: 6170578Nov 1, 1981Paper

Importance of plasma angiotensin concentrations in a comparative study of responses to angiotensin in the maturing newborn lamb

Hypertension
T A WilsonR M Carey

Abstract

Plasma angiotensin concentrations were measured in a longitudinal study of the vascular, renal, and adrenal responses to infusions of angiotensin II (AII) in the maturing newborn lamb. Basal plasma concentrations of angiotensin increased with age and correlated with the rising arterial pressure that occurred with maturation. However, age was a stronger determinant of arterial pressure than was plasma angiotensin concentration. For any given dose of AII per kilogram of body weight, the actual plasma angiotensin concentration achieved increased as the lambs matured and gained weight. Therefore, a comparative study of biologic responses to AII in maturing animals must be based on actual plasma angiotensin concentrations achieved rather than on dose of AII infused per kilogram of body weight. When analyzed on the basis of actual plasma angiotensin concentration, the increase in arterial pressure and the suppression of plasma renin activity in response to increasing plasma angiotensin concentrations did not differ significantly as the lambs matured. However, the increment in plasma aldosterone concentrations in response to increasing plasma angiotensin concentrations was diminished in immature lambs (less than 18 days) when compared...Continue Reading

References

Aug 1, 1979·Kidney International·K J Van AckerH M Neels
Jan 1, 1977·Biology of the Neonate·S SolomonI Serban
Apr 1, 1978·Physiology & Behavior·L F Mercer, N R Remley
Jul 1, 1977·The Journal of Pediatrics·F Broughton Pipkin, O R Smales
Aug 1, 1977·American Journal of Obstetrics and Gynecology·J E RobillardF G Smith
Aug 1, 1976·The Journal of Pediatrics·H P StalkerT A Kotchen
Jul 1, 1976·Archives of Disease in Childhood·M J DillonM de Swiet
Oct 1, 1976·The Journal of Clinical Investigation·J Douglas, K J Catt
Mar 1, 1975·The Journal of Clinical Endocrinology and Metabolism·J SassardJ F Cier
Jan 1, 1968·The Journal of Endocrinology·D P AlexanderR D Wright
Feb 1, 1971·Canadian Journal of Physiology and Pharmacology·P GrangerJ Genest
Jun 1, 1972·The Journal of Pediatrics·T A KotchenD R Walters
Jan 1, 1974·Pflügers Archiv : European journal of physiology·I Pohlová, J Jelínek
Sep 14, 1968·South African Medical Journal = Suid-Afrikaanse Tydskrif Vir Geneeskunde·J M WynneJ H Louw
Feb 1, 1980·Pediatric Research·S R Siegel, D A Fisher
Feb 1, 1965·The Journal of Clinical Investigation·D L BOATMANM J BRODY

❮ Previous
Next ❯

Citations

Dec 1, 1984·Kidney International·T J FiselierP J Lijnen
Dec 3, 2014·Vascular Pharmacology·Angela Elena Vinturache, Francine Gabriel Smith
May 10, 2005·Pediatric Research·Sithembiso C VelaphiCharles R Rosenfeld
Aug 24, 2002·Pediatric Research·Sithembiso C VelaphiCharles R Rosenfeld
Apr 12, 2007·Pediatric Research·Sithembiso C VelaphiCharles R Rosenfeld
Mar 24, 1999·Pediatric Research·B E Cox, C R Rosenfeld
Jun 12, 2004·American Journal of Respiratory Cell and Molecular Biology·Xinmei LiSusan C Olson

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.