PMID: 9194772Jun 1, 1997Paper

Importance of platelets in neutrophil adhesion and vasoconstriction after deep carotid arterial injury by angioplasty in pigs

Arteriosclerosis, Thrombosis, and Vascular Biology
Y MerhiJ G Latour

Abstract

In previous studies we have shown that platelets can support neutrophil adhesion to the injured vessel wall in vitro and that neutrophils contribute to vascular tone regulation after arterial injury in vivo. In this study, we investigated the implication of platelets in neutrophil adhesion and the vasomotor response to arterial injury in vivo. 111In-labeled neutrophil adhesion and angiographic vasoconstriction were quantified after deep carotid arterial injury by balloon angioplasty in normal (n = 8), thrombocytopenic (n = 7), and aspirin-treated (2 mg/kg IV, n = 7) pigs. Thrombocytopenia was produced by a polyclonal antiplatelet serum that depleted circulating platelet count by 84% without influencing neutrophil count. In the control animals, neutrophil adhesion (x 10(4)/cm2) at the site of deep arterial injury averaged 26.8 +/- 4.0 and decreased significantly to 11.5 +/- 2.3 and 11.2 +/- 2.4 in the thrombocytopenic and aspirin groups, respectively. The degree of vasconstriction was also reduced significantly, from 55.5 +/- 3.8% in the control group to 31.4 +/- 6.2% after platelet depletion and to 23.6 +/- 4.5% in the aspirin-treated group. Neutrophil adhesion to intact noninjured adjacent arterial segments was low in all grou...Continue Reading

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Citations

Mar 12, 2004·The Journal of Surgical Research·R G CaseyD J Bouchier-Hayes
Oct 8, 1999·Journal of Cardiovascular Pharmacology·D LibersanJ G Latour
Dec 6, 2003·Journal of Endovascular Therapy : an Official Journal of the International Society of Endovascular Specialists·Jean-François TanguayYahye Merhi
Oct 26, 2005·Anesthesia and Analgesia·Guochang HuGeorge J Crystal
May 26, 2007·The American Journal of Pathology·Risa Tamagawa-MineokaSaburo Kishimoto
Nov 2, 2001·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·K SingbartlK Ley
Jan 6, 2006·Journal of Atherosclerosis and Thrombosis·Takuhito ShojiYoshiki Nishizawa
Mar 14, 2009·The Journal of Allergy and Clinical Immunology·Risa Tamagawa-MineokaSaburo Kishimoto

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