PMID: 11900292Mar 20, 2002Paper

Importance of right and left atrial dilation and linear ablation for perpetuation of sustained atrial fibrillation

Journal of Cardiovascular Electrophysiology
Markus ZarseM A Allessie

Abstract

Atrial dilation associated with increasing atrial pressure plays an apparent role in the development of atrial fibrillation (AF). We characterized a new model of separate and biatrial dilation in the Langendorff-perfused rabbit heart. The aim of this study was to examine if sustained AF in this model (1) would be inducible by separate right atrial (RA) and left atrial (LA) dilation; (2) would be reproducibly inducible at the same pressure level; and (3) could be suppressed by RA, LA, or biatrial ablation. Intra-atrial pressure was increased stepwise in the RA (n = 13), LA (n = 12), or both atria (n = 25) until sustained AF could be induced or a pressure of 20 cm H2O was reached. The stimulation protocol was repeated once in RA and LA dilation (n = 9) and three times in biatrial dilation (n = 7). Then, RA orifices (superior and inferior caval veins, tricuspid valve annulus, and foramen ovale) or LA orifices (pulmonary veins, mitral valve annulus, and foramen ovale) were connected by radiofrequency (RF) lesions. Sustained AF was rendered inducible in 100% of hearts with biatrial dilation, but in only 92% of hearts with RA dilation and 67% with LA dilation. Inducibility of sustained AF was reproducible. Under biatrial dilation, no...Continue Reading

Citations

Mar 8, 2008·Journal of Interventional Cardiac Electrophysiology : an International Journal of Arrhythmias and Pacing·Giovanni B ForleoClaudio Tondo
Jun 17, 2008·Molecular and Cellular Biochemistry·Jérôme KalifaMonique Bernard
Feb 5, 2013·Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology·Peter MilbergLars Eckardt
Apr 29, 2003·Journal of Cardiovascular Electrophysiology·Penelope A Boyden
Jun 20, 2006·Journal of the American College of Cardiology·Leonardo CalòMassimo Santini
Mar 1, 2012·International Journal of Cardiology·Judith BouchardyJudith Therrien
May 24, 2016·Circulation Journal : Official Journal of the Japanese Circulation Society·Jin WiYangsoo Jang
Nov 1, 2005·Journal of Veterinary Cardiology : the Official Journal of the European Society of Veterinary Cardiology·Pierre MenautN Sydney Moïse
Jun 27, 2006·Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology·Lena LöfbergLeif Carlsson
Sep 9, 2021·Clinical Cardiology·Timm SeewösterJelena Kornej

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