Importance of RIP140 and LCoR Sub-Cellular Localization for Their Association With Breast Cancer Aggressiveness and Patient Survival

Translational Oncology
Sophie SixouVincent Cavailles

Abstract

New markers are needed to improve diagnosis and to personalize treatments for patients with breast cancer (BC). Receptor-interacting protein of 140 kDa (RIP140) and ligand-dependent corepressor (LCoR), two transcriptional co-regulators of estrogen receptors, strongly interact in BC cells. Although their role in cancer progression has been outlined in the last few years, their function in BC has not been elucidated yet. In this study, we investigated RIP140 and LCoR localization (cytoplasm vs nucleus) in BC samples from a well-characterized cohort of patients (n = 320). RIP140 and LCoR were expressed in more than 80% of tumors, (predominantly in the cytoplasm), and the two markers were highly correlated. Expression of RIP140 and LCoR in the nucleus was negatively correlated with tumor size. Conversely, RIP140 and LCoR cytoplasmic expression strongly correlated with expression of two tumor aggressiveness markers: N-cadherin and CD133 (epithelial mesenchymal transition and cancer stem cell markers, respectively). Finally, high RIP140 nuclear expression was significantly correlated with longer overall survival, whereas high total or cytoplasmic expression of RIP140 was associated with shorter disease-free survival. Our study strong...Continue Reading

Citations

Jan 24, 2019·International Journal of Molecular Sciences·Katharina MüllerUdo Jeschke
May 30, 2019·Oncotarget·Hanine LattoufMuriel Le Romancer
Mar 1, 2019·International Journal of Molecular Sciences·Udo JeschkeVincent Cavaillès
Nov 7, 2019·Nutrients·Samantha A HutchinsonJames L Thorne
Feb 23, 2020·Journal of Translational Medicine·Wanting ShaoSophie Sixou
Jun 5, 2021·Journal of Cancer Research and Clinical Oncology·Wanting ShaoSophie Sixou

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