PMID: 9164247May 1, 1997Paper

Importance of sphingolipids and inhibitors of sphingolipid metabolism as components of animal diets

The Journal of Nutrition
A H MerrillR T Riley

Abstract

Sphingolipids are highly bioactive compounds that participate in the regulation of cell growth, differentiation, diverse cell functions, and apoptosis. They are present in both plant and animal foods in appreciable amounts, but little is known about their nutritional significance. Recent studies have shown that feeding sphingomyelin to female CF1 mice treated with a colon carcinogen (1,2-dimethylhydrazine) reduced the number of aberrant colonic crypt foci; longer-term feeding also affected the appearance of colonic adenocarcinomas. Therefore, dietary sphingolipids should be considered in studies of the relationships between diet and cancer. Sphingolipids have also surfaced as important factors in understanding the mechanism of action of a recently discovered family of mycotoxins, termed fumonisins. Fumonisins are produced by fungi commonly found on maize and a few related foods, and their consumption can result in equine leukoencephalomalacia, porcine pulmonary edema and a number of other diseases of veterinary animals and, perhaps, humans. A cellular target of fumonisins is the enzyme ceramide synthase, and disruption of sphingolipid metabolism by fumonisins has been established by studies with both cells in culture and animal...Continue Reading

References

Jun 15, 1995·Biochemical and Biophysical Research Communications·Y MiyakeT Kawasaki
May 1, 1994·The Journal of Nutrition·D L DillehayA H Merrill
May 1, 1994·The Journal of Nutrition·E M SchmelzA H Merrill
Jun 1, 1996·Trends in Cell Biology·A H MerrillR T Riley
Jul 1, 1994·Journal of Food Protection·Ronald T RileyAlfred H Merrill

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Citations

Jan 20, 2007·Journal of Dairy Science·E L F GravesJ K Drackley
Sep 30, 2016·Biochemistry. Biokhimii︠a︡·D I Kuzmenko, T K Klimentyeva
Jun 18, 2016·Clinical and Translational Allergy·Katrine Lindholm BøghLiam O'Mahony
Aug 15, 2000·Annual Review of Nutrition·W H WatsonD P Jones
Jul 24, 2002·European Journal of Biochemistry·Mahin Ghanevati, Jan G Jaworski
Sep 19, 2006·Molecular and Cellular Biology·Masataka KohnoTimothy Hla
Nov 11, 2003·The Journal of Nutrition·Sang K Noh, Sung I Koo
Feb 27, 2018·Applied Microbiology and Biotechnology·Yong FanFu-Li Li
Mar 4, 2000·Journal of Pediatric Gastroenterology and Nutrition·A BergerG Crozier
Apr 3, 2003·Journal of Lipid Research·Rui-Dong DuanAke Nilsson
Mar 4, 2006·The British Journal of Nutrition·J BarrenetxeE Urdaneta
Feb 24, 2012·PloS One·Radha DuttaguptaKeith W Jones
Oct 6, 2020·Evidence-based Complementary and Alternative Medicine : ECAM·Rui WuJinyao Chen
Aug 11, 2020·The Plant Journal : for Cell and Molecular Biology·Qiuyue MaQianzhong Li
Feb 9, 2021·Journal of Environmental Science and Health. Part C, Toxicology and Carcinogenesis·Ruth Nabwire Wangia-Dixon, Kizito Nishimwe
Apr 21, 2001·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·M SolfrizzoA Visconti
Mar 5, 2003·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·J H Exon, E H South
Jul 26, 2002·Journal of Agricultural and Food Chemistry·Shengmin SangChi-Tang Ho

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