Importance of stereospecific bioanalytical monitoring in drug development

Journal of Chromatography. a
J Caldwell

Abstract

The role of the bioanalyst in the support of drug discovery and development is described with particular emphasis upon stereospecific assays for the individual optical isomers of chiral drugs. The significance of the stereochemical aspects of pharmacokinetics and drug metabolism in both preclinical and clinical development is summarized and illustrated with reference to the pharmacogenetic polymorphisms of drug oxidation existing in the human population. The significance of stereochemical considerations in drug metabolism and pharmacokinetics has recently become an issue for both the pharmaceutical industry and the regulatory authorities, driven to a great extent by recent developments in methodology for both the analytical and preparative resolution of racemic drug mixtures. Ths has led to the so-called 'racemate-versus-enantiomer' debate in recent years. The development of regulatory attitudes in the major jurisdictions of the world to the development of new drugs containing one or more chiral centres is outlined.

Citations

Mar 31, 2005·Rapid Communications in Mass Spectrometry : RCM·Zhongzhou ShenStella Vincent
Mar 1, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Carla FernandesMadalena M M Pinto
Jan 10, 2003·Chirality·Christopher J WelchDavid J Mathre
Feb 3, 2007·Physical Chemistry Chemical Physics : PCCP·Marco BieriThomas Bürgi
Feb 29, 2008·Chirality·Gilberto AlvesPatrício Soares-Da-Silva
Jun 23, 2018·Journal of Chromatographic Science·Mohamed Nadjib RebiziHassan Y Aboul-Enein
Feb 27, 2007·Journal of Clinical Pharmacology·Ronda K RippleyJohn A Wagner
Mar 3, 2012·Oncotarget·Julie S Barber-RotenbergJeffrey A Toretsky
May 2, 2002·Chirality·Joanna Szymura-OleksiakHassan Y Aboul-Enein
Feb 12, 2021·Electrophoresis·Jitka Caslavska, Wolfgang Thormann
Jun 20, 2021·Bioorganic & Medicinal Chemistry Letters·Murilo K A YonekawaEdson Dos A Dos Santos
Nov 23, 2021·Chirality·Hassan Y Aboul-EneinSelvakumar Kanthiah

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

American Journal of Health-system Pharmacy : AJHP : Official Journal of the American Society of Health-System Pharmacists
Kristine K HahnJill M Kolesar
© 2021 Meta ULC. All rights reserved