Importance of sustained and "tight" blood pressure control in patients with high cardiovascular risk

Blood Pressure
Peter A MeredithHenry L Elliott

Abstract

A retrospective further analysis of the ACTION database evaluated the relationship between cardiovascular outcomes and the "quality" of the control of blood pressure (BP). The study population (n = 6287) comprised those patients with four BP measurements during year 1 subdivided according to the proportion of visits in which BP was controlled in relation to two BP targets: < 140/90mmHg and < 130/80 mmHg. Differences between the BP control groups for the major prespecified ACTION outcomes were investigated with Cox proportional hazards models. For all the prespecified cardiovascular endpoints the incidence declined as the proportion of visits with BP control increased. The greatest differences in outcomes between the different BP control groups were observed for the risk of stroke but were still apparent for all the other endpoints. For example, the risks for the primary outcome [hazard ratio (HR) 0.78; 95% confidence interval (CI) 0.67 to 0.90] were significantly less in the group with >_75% of visits with BP control than in the group with < 25% of visits with BP control. There were no significant treatment-related differences. Retrospective analyses are not definitive but these results highlight the importance of the attainmen...Continue Reading

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Citations

Feb 14, 2016·Blood Pressure·Henry L ElliottThomas Hedner
Oct 30, 2016·Progress in Cardiovascular Diseases·Julian E MariampillaiGiuseppe Mancia
Jun 6, 2020·Journal of the American Geriatrics Society·C Barrett BowlingPaul Muntner
Jan 21, 2017·Nature Reviews. Endocrinology·Pantelis A SarafidisLuis M Ruilope

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