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Importance of the aromatic ring in adrenergic amines. 2. Synthesis and adrenergic activity of some nonaromatic six- and eight-membered ring analogs of beta-phenylethanolamine

Journal of Medicinal Chemistry

Jan 1, 1976

Gary L GrunewaldKadhim N Salman

PMID: 1534

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Abstract

The synthesis of beta-phenylethanolamine analogs in which the phenyl ring is replaced by cyclohexyl, cyclohexen-4-yl, cyclooctyl, cyclooctenyl, cycloocta-1,3-dien-2-yl, cycloocta-1,5-dienyl, and cyclooctatetraenyl was accompanied by conversion of the corresponding aldehydes to the cyano...read more

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Vas Deferens Structure
Benzene
Analogs & derivatives
Smooth Muscle
2-Hydroxyphenethylamine
Analog
Phenethylamines
Ethanolamines
Norepinephrine
Lithium
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  • Importance of the aromatic ring in adrenergic amines. 2. Synthesis and adrenergic activity of some nonaromatic six- and eight-membered ring analogs of beta-phenylethanolamine

    Journal of Medicinal Chemistry

    Jan 1, 1976

    Gary L GrunewaldKadhim N Salman

    PMID: 1534

    DOI:

    Abstract

    The synthesis of beta-phenylethanolamine analogs in which the phenyl ring is replaced by cyclohexyl, cyclohexen-4-yl, cyclooctyl, cyclooctenyl, cycloocta-1,3-dien-2-yl, cycloocta-1,5-dienyl, and cyclooctatetraenyl was accompanied by conversion of the corresponding aldehydes to the cyano...read more

    Mentioned in this Paper

    Vas Deferens Structure
    Benzene
    Analogs & derivatives
    Smooth Muscle
    2-Hydroxyphenethylamine

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