PMID: 9523533Apr 2, 1998Paper

Importance of the treatment field for the application of vascular photodynamic therapy to inhibit intimal hyperplasia

Photochemistry and Photobiology
R G Statius van EpsG M LaMuraglia

Abstract

Intimal hyperplasia (IH) plays a dominant role in the development of restenosis. In previous studies, photodynamic therapy (PDT) prevented IH induced by segmental balloon injury of the rat carotid. The critical elements required to control IH effectively with this technique are not fully understood. This study assessed the importance of the treatment field by studying the repair process of injured vessels, in which the PDT-treatment field did not target the entire injured area. The entire rat common carotid artery was balloon-injured to induce IH, whereas only the cervical segment below the bifurcation was subjected to PDT by external light irradiation after administration of the photosensitizer chloroaluminum sulfonated phthalocyanine. Light irradiation of injured arteries without photosensitizer served as control for PDT, and PDT of uninjured arteries was included as a control group for the balloon injury. Histologic characterization of the repair process was sequentially assessed. Balloon-injured arteries without PDT displayed rapid IH development with a peak at 2 weeks. Photodynamic therapy of balloon-injured arteries resulted in complete local depletion of medial smooth muscle cells (SMC), which was associated with a lack ...Continue Reading

Citations

Jan 12, 2001·Journal of Photochemistry and Photobiology. B, Biology·A VisonàG Jori
Feb 14, 2002·Photochemistry and Photobiology·Peter R WatermanGlenn M LaMuraglia
Sep 27, 2002·European Journal of Vascular and Endovascular Surgery : the Official Journal of the European Society for Vascular Surgery·E E E GabelerH van Urk
Oct 23, 2002·European Journal of Vascular and Endovascular Surgery : the Official Journal of the European Society for Vascular Surgery·F AdiliT Schmitz-Rixen
Oct 30, 2015·Science Translational Medicine·Uma Mahesh R AvulaJérôme Kalifa
Nov 29, 2016·Cardiovascular Therapeutics·Manish JainMarie-Noelle Giraud
May 22, 2007·European Journal of Vascular and Endovascular Surgery : the Official Journal of the European Society for Vascular Surgery·J HeckenkampE Mattsson

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