Importance of the treatment package time in surgery and postoperative radiation therapy for squamous carcinoma of the head and neck

Head & Neck
David I RosenthalMitchell Machtay

Abstract

To determine the effect of treatment time-related factors on outcome in patients treated with surgery and postoperative radiation therapy (RT) for locally advanced squamous cell carcinoma of head and neck (SCCHN) METHODS: A retrospective review was performed on 208 consecutive patients treated from 1992 to 1997 with surgery and postoperative RT (> or =55 Gy) for SCCHN. The treatment time factors considered were (1) interval from surgery to the start of RT; (2) RT duration; and (3) the total time from surgery to completion of RT (treatment package time). Treatment package time was dichotomized into short (< or =100 days) vs long (>100 days) categories. Other variables considered were clinical and pathologic staging, margin status, RT dose, and tumor site. Patients were also divided into intermediate- and high-risk groups on the basis of eligibility for RTOG 95-01. Univariate (logrank) and multivariate analyses were performed. Median follow-up for surviving patients was 24 months. Actuarial 2-year locoregional control (LRC) and survival rates were 82% and 71%, respectively. In univariate analysis, factors associated with higher locoregional failure were high-risk group (p =.011), margin status (p =.038), pathologic stage (p =.035...Continue Reading

References

Dec 1, 1992·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·J H Hendry
Jan 1, 1992·International Journal of Radiation Oncology, Biology, Physics·G E LaramoreJ G Schwade
Aug 1, 1991·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·E E VokesR R Weichselbaum
Aug 1, 1989·International Journal of Radiation Oncology, Biology, Physics·R J AmdurN J Cassisi
Jan 1, 1988·Acta Oncologica·H R WithersB Maciejewski
Apr 1, 1982·The Laryngoscope·S A El BadawiM J Oswald
Jul 1, 1994·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·S M Bentzen
Jan 1, 1994·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·J F Fowler, R Chappell
Jan 1, 1994·International Journal of Radiation Oncology, Biology, Physics·D I RosenthalE Glatstein
Apr 30, 1993·International Journal of Radiation Oncology, Biology, Physics·L J PetersR A Frankenthaler
Sep 1, 1995·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·W Van den BogaertE van der Schueren
Dec 1, 1996·International Journal of Radiation Oncology, Biology, Physics·J M BachaudN Daly-Schveitzer
Aug 1, 1997·International Journal of Radiation Oncology, Biology, Physics·J T ParsonsR R Million
Nov 22, 1997·International Journal of Radiation Oncology, Biology, Physics·L J Peters, H R Withers
Mar 5, 1998·International Journal of Radiation Oncology, Biology, Physics·L J Peters
Mar 5, 1998·International Journal of Radiation Oncology, Biology, Physics·R E LundahlK D Olsen
Apr 29, 1998·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·M Al-SarrafJ F Ensley
Aug 5, 2000·International Journal of Radiation Oncology, Biology, Physics·H R Withers, L J Peters

❮ Previous
Next ❯

Citations

Feb 11, 2004·Clinical Oncology : a Journal of the Royal College of Radiologists·G Macdonald, D C Hurman
Feb 15, 2005·International Journal of Radiation Oncology, Biology, Physics·Giuseppe SanguinetiPaolo Antognoni
Oct 7, 2004·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·Gideon MarshakBaruch Brenner
Feb 6, 2007·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·Federico L AmpilEdward Milligan
Apr 10, 2007·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·Matthew SchwartzHoracio Patrocinio
May 10, 2003·International Journal of Radiation Oncology, Biology, Physics·Rafal SuwinskiBoguslaw Maciejewski
Nov 3, 2005·Nature Clinical Practice. Oncology·Sue S Yom, David I Rosenthal
Feb 24, 2011·Annals of Oncology : Official Journal of the European Society for Medical Oncology·L LicitraE Tagliabue
Oct 1, 2010·American Journal of Clinical Oncology·Gregory J KubicekSteven K Williamson
Sep 22, 2006·Clinical Medicine & Research·William M MendenhallDouglas B Villaret
Aug 21, 2013·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·Young-Hoon JooMin-Sik Kim
Aug 28, 2014·Nihon Jibiinkoka Gakkai kaiho·Motoyuki SuzukiKoji Kitamura
Apr 14, 2016·Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology·Courtney HentzMehee Choi
Mar 1, 2012·Expert Review of Anticancer Therapy·Meredith JohnstonJohn Kim
Oct 8, 2003·International Journal of Radiation Biology·R Suwinski, H R Withers
Oct 4, 2011·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Chien P ChenSue S Yom
Aug 21, 2013·American Journal of Otolaryngology·Megan E DalyAllen M Chen
Dec 12, 2012·Cancer radiothérapie : journal de la Société française de radiothérapie oncologique·S Renard-OldriniD Peiffert
Dec 1, 2015·International Journal of Oral and Maxillofacial Surgery·X YangC Zhang
May 14, 2008·International Journal of Radiation Oncology, Biology, Physics·Chun-Ta LiaoTzu-Chen Yen
Nov 1, 2006·The Laryngoscope·Jacob D SteigerJames N Palmer
Feb 6, 2007·The Laryngoscope·Ikuo HyodoShuhei Torii
Dec 14, 2011·Head & Neck·Primož StrojanCarl E Silver
Sep 20, 2005·Cancer radiothérapie : journal de la Société française de radiothérapie oncologique·M Schlienger
Jun 28, 2005·Critical Reviews in Oncology/hematology·Jacques BernierJay S Cooper
Sep 17, 2013·Acta Oto-laryngologica·Young-Hoon JooMin-Sik Kim

❮ Previous
Next ❯

Related Concepts

Related Feeds

Carcinoma, Squamous Cell

Basal cell carcinoma is a form of malignant skin cancer found on the head and neck regions and has low rates of metastasis. Discover the latest research on basal cell carcinoma here.

Related Papers

International Journal of Radiation Oncology, Biology, Physics
Johannes A LangendijkB J Slotman
Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology
V P MurielJ de Dios Luna del Castillo
International Journal of Radiation Oncology, Biology, Physics
Rafal SuwinskiB Maciejewski
© 2021 Meta ULC. All rights reserved