Important cytotoxic and cytostatic effects of new copper(i)-phosphane compounds with N,N, N,O and N,S bidentate ligands

Dalton Transactions : an International Journal of Inorganic Chemistry
Tânia S MoraisM Helena Garcia

Abstract

A family of six phosphane Cu(i) complexes bearing N,N, N,O and N,S bidentate ligands was synthesized. All the compounds were fully characterized by classical analytical and spectroscopic methods, and five of them were also characterized by X-ray diffraction studies. All the compounds exhibit high cytotoxicity against the human breast cancer cell line MCF7 with IC50 values far lower than those found for cisplatin, a current chemotherapeutic in clinical use. Compounds 1[combining low line] and 3[combining low line] induce cell cycle arrest in the G2/M phase and cell death by apoptosis. The cytotoxic and cytostatic effects of these compounds on MCF7 cells suggest that they are suitable for further in vivo studies with breast cancer models.

References

Aug 28, 2003·Current Opinion in Chemical Biology·Christiana Xin Zhang, Stephen J Lippard
Sep 11, 2004·Frontiers in Bioscience : a Journal and Virtual Library·Kenyon G DanielQ Ping Dou
Dec 25, 2007·Acta Crystallographica. Section A, Foundations of Crystallography·George M Sheldrick
Sep 9, 2008·Cancer Treatment Reviews·Anshul Gupte, Russell J Mumper
Jan 28, 2009·Acta Crystallographica. Section D, Biological Crystallography·Anthony L Spek
Feb 10, 2009·Anti-cancer Agents in Medicinal Chemistry·Cristina MarzanoCarlo Santini
Apr 10, 2009·Current Medicinal Chemistry·Saverio Tardito, Luciano Marchiò
Jun 11, 2010·Dalton Transactions : an International Journal of Inorganic Chemistry·Luca Domenico D'AndreaCarlo Pedone
Jan 1, 2008·Acta Crystallographica. Section E, Structure Reports Online·Maribel NavarroMario V Capparelli
Mar 2, 2011·Nature Reviews. Drug Discovery·Oliver KeppGuido Kroemer
Mar 11, 2011·Journal of Cellular and Molecular Medicine·Valentina GandinCristina Marzano
Jun 9, 2012·Dalton Transactions : an International Journal of Inorganic Chemistry·Inmaculada Andrés-ToméPaolo Coppo
Nov 13, 2012·International Journal of Nanomedicine·Eleonore Fröhlich
Aug 24, 2013·Journal of Medicinal Chemistry·Valentina GandinCristina Marzano
Oct 10, 2013·Chemical Reviews·Carlo SantiniCristina Marzano
Apr 22, 2014·Biometals : an International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine·Anna HordyjewskaJoanna Kocot
Jun 17, 2015·Journal of Biological Inorganic Chemistry : JBIC : a Publication of the Society of Biological Inorganic Chemistry·Ana Soraia MendoAlexandra R Fernandes
Aug 28, 2015·Metallomics : Integrated Biometal Science·Delphine DenoyerMichael A Cater
Jan 13, 2016·World Journal of Gastroenterology : WJG·Jason Wachsmann, Fangyu Peng
Feb 5, 2016·Biochimica Et Biophysica Acta·Danuta S KalinowskiDes R Richardson
Feb 26, 2016·Dalton Transactions : an International Journal of Inorganic Chemistry·Zhen MaArmando J L Pombeiro
Jun 17, 2016·European Journal of Medicinal Chemistry·Zhenlei ZhangFeng Yang
Jul 18, 2016·European Journal of Medicinal Chemistry·Nandini MukherjeeAkhil R Chakravarty
Jul 14, 2017·Dalton Transactions : an International Journal of Inorganic Chemistry·Katarzyna CzerwińskaGeorgiy B Shul'pin
Jul 14, 2017·Dalton Transactions : an International Journal of Inorganic Chemistry·Mohamed WehbeMarcel B Bally

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Citations

Aug 26, 2020·Dalton Transactions : an International Journal of Inorganic Chemistry·João Franco MachadoTânia S Morais
Jan 21, 2021·Dalton Transactions : an International Journal of Inorganic Chemistry·Diogo SequeiraAlexandra R Fernandes
Jun 3, 2021·Biomedicines·Damiano CirriTiziano Marzo
Jan 9, 2020·ACS Combinatorial Science·Nazanin KordestaniOlivier Blacque

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Methods Mentioned

BETA
NMR
X-ray
fluorescence microscopy
flow cytometry
FCS

Software Mentioned

SHELXS
FCS Express 6
SAINT
APEX2
SHELXL
SMART
MERCURY
GraphPad Prism
WINGX
EAGER

Related Concepts

Related Feeds

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis